2012 Fiscal Year Final Research Report
Basic study as to stress maladjustment and effect of a self-management program in patients with systemic lupus erythematosus.
| Project/Area Number |
22792209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical nursing
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| Research Institution | Kwassui Women's College |
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Principal Investigator |
MATSUURA Emi 活水女子大学, 看護学部看護学科, 准教授 (20363426)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 膠原病 / ストレス / 自己管理 |
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| Research Abstract |
To clarify the evidence of any functional disturbances inhypothalamic-pituitary-adrenal (HPA) axis as a homeostatic system upon stress in patients with systemic lupus erythematosus. Various serum levels of stress-related hormones were examined before and after a mental calculation stress test, and a basal questionnaire study as to sense of coherence (SOC), recent stress experiences, and quality of life (QOL) was performed, in 30 patients with systemic lupus erythematosus (SLE), and also in 38 healthy volunteers.Basal physical QOL state decreased in the patients, and mental QOL decreased in SLE patients, but there was little difference in recent stress experiences and SOC scores between patients and controls. Basal cortisol and noradrenalin levels were higher in the patients. Characteristically, contrary to the control group whose cortisol andβ-endorphin levels increased significantly following the stress test, no significantdifferences were seen in their levels between pre- and post-test in both of the patients, suggesting a defect in normal stress-response system in patients. The present results suggest that in SLE patients there may be an impaired function in stress-adaptationsystem.
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