2011 Fiscal Year Final Research Report
Characterization and in vivo evaluation of nano-sized polyion complex vesicles with varying elasticity
| Project/Area Number |
22810009
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Nanomaterials/Nanobioscience
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
ANRAKU Yasutaka 東京大学, 大学院・工学系研究科, 特任研究員 (60581585)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 自己組織化中空粒子 / ドラッグデリバリーシステム / 弾性率 / 体内動態 |
|---|
| Research Abstract |
We have previously demonstrated interesting properties in spontaneously formed submicron-sized polyion complex vesicles(Nano-PICsomes) via the self-assembly of a pair of oppositely charged polymers, whereby cross-linking of the PIC membrane by a condensation reagent can control many properties, including improvement of blood circulation and biodistribution. In this time, we succeeded in the characterization and in vivo evaluation of Nano-PICsomes with various cross-linking ratios and sizes.
|
