2011 Fiscal Year Final Research Report
the molecular mechanism of dorso-ventral patterning in late stages of development
| Project/Area Number |
22870008
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 後期発生 / 背腹パターン / Zic1/Zic4 |
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| Research Abstract |
We analyzed the molecular function of transcription factors Zic1/Zic4, which express in dorsal somites and regulate dorso-ventral patterning of body trunk. We performed transcriptome analyses using Da mutants, which lost the expression of Zic1/Zic4 specifically in somites and identified several downstream genes of Zic1/Zic4. We found that the modulator of Notch signaling, lunatic fringe, is one of the downstream target of Zic1/Zic4, suggesting that Zic1/Zic4 contribute the dorsal trunk morphology by reguating the activity of Notch signaling. We generated and analyzed several mouse lines to understand the conserved function and expression of Zic1/Zic4.
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[Journal Article] The Medaka zic1/zic4 Mutant Provides Molecular Insights into Teleost Caudal Fin Evolution2012
Author(s)
Moriyama Y, Kawanishi T, Nakamura R, Tsukahara T, Sumiyama K, Suster ML, Kawakami K, Toyoda A, Fujiyama A, Yasuoka Y, Nagao Y, Sawatari E, Shimizu A, Wakamatsu Y, Hibi M, Taira M, Okabe M, Naruse K, HashimotoH, Shimada A, Takeda H
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Journal Title
Current biology
Volume: vol.22
Pages: 601-607
URL
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