2011 Fiscal Year Final Research Report
Global analysis of aggregation-inhibition effects of molecular chaperones
| Project/Area Number |
22870010
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
NIWA Tatsuya 東京工業大学, 大学院・生命理工学研究科, 助教 (50588530)
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| Research Collaborator |
TAGUCHI Hideki 東京工業大学, 大学院・生命理工学研究科, 教授 (40272710)
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| Project Period (FY) |
2010 – 2011
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| Keywords | タンパク質のフォールディング / タンパク質凝集 / 分子シャペロン |
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| Research Abstract |
Comprehensive analysis of aggregation-inhibition effects of three major molecular chaperones working in Escherichia coli was conducted for~ 800 aggregation-prone cytosolic proteins. The results revealed that many of the~ 800 aggregation-prone proteins were solubilized by either one of the two chaperones and most of the proteins that were not solubilized by either one of the three were solubilized by the combination of the three chaperone.
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Research Products
(7 results)
