2011 Fiscal Year Final Research Report
Functional analysis of small RNA in the reprogramming process from differentiated cells to pluripotent stem cells
| Project/Area Number |
22870036
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Plant molecular biology/Plant physiology
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
TAMADA Yosuke 基礎生物学研究所, 生物進化研究部門, 助教 (50579290)
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| Research Collaborator |
HASEBE Mitsuyasu 基礎生物学研究所, 生物進化研究部門, 教授 (40237996)
MORI Hitoshi 名古屋大学, 大学院・生命農学研究科, 教授 (20220014)
LI Chen 総合研究大学院大学, 生命科学研究科, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Keywords | リプログラミング / 幹細胞 / 低分子RNA / ヒメツリガネゴケ |
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| Research Abstract |
We had found that expression of small RNAs is globally reduced during reprogramming in the moss Physcomitrella patens. We hypothesized that PpCSP proteins are involved in this process. PpCSP is presumed to function in the repression of the microRNA(miRNA) maturation. Here we found that PpCSP was localized in cytosol, and a PpCSP lesion caused attenuated reprogramming. These data suggest that PpCSP facilitates reprogramming through repressing the miRNA maturation in cytosol. To verify this hypothesis, we have performed the functional analyses of PpCSP.
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[Remarks] (2) The 53rd annual meeting of the Japanese society of plant physiologistsにおいて、シンポジウム"Response to environmental/developmental signals and regulation of epigenetic state of chromatin"をオーガナイズした。
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[Remarks] (3) The 52rd annual meeting of the Japanese society of plant physiologistsにおいて、シンポジウム"Frontier of Epigenetics : Regulation and function of chromatin modifications"をオーガナイズした。当シンポジウムはPlant and Cell Physiology誌のFirst sponsored symposiumに選出され、特集号"Plant Epigen
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