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2011 Fiscal Year Final Research Report

Research on the synergistic enhancement of physiological functions by food components

Research Project

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Project/Area Number 22880024
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionKyushu University

Principal Investigator

TANAKA Mitsuru  九州大学, 農学研究院, 特任助教 (70584209)

Project Period (FY) 2010 – 2011
Keywords食相乗性 / ペプチド / 血管機能
Research Abstract

The aim of this study is to demonstrate the enhancement of the small peptide Trp-His-induced vasorelaxation by food components. We found that epigallocatechin gallate(EGCg) dramatically enhanced the Trp-His-induced vasorelaxation. The present study also suggests that the Trp-His-induced vasorelaxation is significantly potentiated by the activation of the NO/cGMP pathway by EGCg.

  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (9 results) Book (2 results)

  • [Journal Article] The anti-therosclerotic di用eptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca^2+ channels in rat vascular smooth muscle cells2012

    • Author(s)
      Y. Kobayashi, T. Fukuda, M. Tanaka, T. Matsui
    • Journal Title

      FEBS Open Bio

      Volume: 2 Pages: 83-88

    • Peer Reviewed
  • [Journal Article] 血管機能とペプチド2011

    • Author(s)
      松井利郎, 田中充
    • Journal Title

      New Food Industry

      Volume: 53 Pages: 22-30

  • [Journal Article] Tip-His, a vasorelaxant di用eptide, can inhibit extra cellular Ca' entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like L-type Ca^<2+> channels2010

    • Author(s)
      Z. Wang, S. Watanabe, Y. Kobayashi, M. Tanaka, T. Matsui
    • Journal Title

      Peptides

      Volume: 31 Pages: 2060-2066

    • Peer Reviewed
  • [Presentation] 低分子ペプチドTrp-HisとEGCgとの相乗的血管弛緩作用はNO/cGMP系賦活化を介て発現する2012

    • Author(s)
      田中充、須山晶,趙健,松井利郎
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2012-05-19
  • [Presentation] 抗動脈硬化ペプチドTrp-Hisは血管平滑筋細胞でのL型Ca2+チャンネルのリン酸化を抑制する2012

    • Author(s)
      福田俊彦,小林優多郎,田中充松井利郎
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学(宮城県)
    • Year and Date
      2012-05-19
  • [Presentation] グリシニン酵素加水分解物からの血管平滑筋細胞内Ca2+流入阻害ペプチドの検索2011

    • Author(s)
      松村慎也,王正全,田中充,松井利郎
    • Organizer
      平成23年日本栄養・食糧学会九州・沖縄支部及び日本食品科学工学会西日本支部合同大会
    • Place of Presentation
      佐賀大学(佐賀県)
    • Year and Date
      2011-09-04
  • [Presentation] 血管平滑筋細胞における抗動脈硬化ペプチドTrp-Hisの細胞内Ca^<2+>シグナル系制御機構の解明2011

    • Author(s)
      小林優多郎,福田俊彦,田中充,松井利郎
    • Organizer
      平成23年日本栄養・食糧学会九州・沖縄支部及び日本食品科学工学会西日本支部合同大会
    • Place of Presentation
      佐賀大学(佐賀県)
    • Year and Date
      2011-09-04
  • [Presentation] 低分子ペプチドの生理機能相乗作用に関する研究(1);ポリフェノールによる血管弛緩性ペプチドの増強作用2011

    • Author(s)
      田中充,松井利郎
    • Organizer
      第65回日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学(東京都)
    • Year and Date
      2011-05-14
  • [Presentation] Matsui. Antiatherosclerotic effect of a small peptide, Tip-His, in apolipoprotein E deficient mice2010

    • Author(s)
      M. Tanaka, Z. Wang, Y. Kobayashi, T.
    • Organizer
      China-Japan Joint Symposium on Food Science & Technology of Food Industry Level
    • Place of Presentation
      中国
    • Year and Date
      2010-11-03
  • [Presentation] A small peptide, Tip-His, that improves vascular health can act as a Ca^<2+> channel blacker2010

    • Author(s)
      Y. Kobayashi, Z. Wang, M. Tanaka, T. Matsui
    • Organizer
      China-Japan Joint Symposium on Food Science & Technology of Food Industry Level
    • Place of Presentation
      中国
    • Year and Date
      2010-11-03
  • [Presentation] Antiatherosclerotic dipeptide, Tip-His, can suppress intracellular[ Ca^<2+>] in vascular smooth muscle cells in a similar manner to dihydropyridine type Ca^<2+> channel blocker2010

    • Author(s)
      Z. Q. Wang, M. Tanaka, S. Watanabe, Y. Kobayashi, T. Matsui
    • Organizer
      The 23rd Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Canada
    • Year and Date
      2010-09-30
  • [Presentation] 血管平滑筋細胞を用いた血管機能改善ジペプチドTrp-HisのL型Ca^<2+>チャンネルに対する結合部位の解明2010

    • Author(s)
      小林優多郎,王正全,渡邊慎平,田中充,松井利郎
    • Organizer
      第57回日本食品科学工学会
    • Place of Presentation
      東京農業大学(東京都)
    • Year and Date
      2010-09-03
  • [Book] Chapter 2. Vascular regulation by small peptides : Bioactive Natural Products : Opportunities & Ch all enges in Medicinal Chemistry2012

    • Author(s)
      T. Matsui, Z. Wang, M. Tanaka
    • Total Pages
      20-221
    • Publisher
      World Scientific Publishing Co.
  • [Book] Chapter 4. Antihypertensive peptides and their underlying mechanism : Bioactive Proteins and Peptides as Functional Foods and Nu traceu ticals2010

    • Author(s)
      T. Matsui, M. Tanaka
    • Total Pages
      43-54
    • Publisher
      Institute of Food Technologists

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Published: 2013-07-31  

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