2011 Fiscal Year Final Research Report
Functional role of reactive oxygen species in hematopoiesis
| Project/Area Number |
22890042
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Keywords | 活性酸素 / 造血幹細胞 / 造血前駆細胞 / 造血細胞分化 / CSF1R |
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| Research Abstract |
While reactive oxygen species(ROS) have been known as harmful substances, it has been noted recently that ROS are critical mediators in cellular homeostasis. In this study, we revealed that intracellular ROS level of megakaryocyte-erythrocyte progenitor cells(MEP) was kept low. Furthermore, we revealed that ROS inhibited the generation of MEP. This study indicates the importance of ROS in hematopoiesis and the possibility that control of ROS is useful for effective generation of blood cells.
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