2011 Fiscal Year Final Research Report
The roles of DRR1 in tumorigenesis and nerve system
| Project/Area Number |
22890080
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
MU Ping 名古屋大学, 大学院・医学系研究科, 助教 (10584675)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 腫瘍抑制 / 神経発生 / DRR1 |
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| Research Abstract |
After the overexpression of DRR1 in neuroblastoma cells, cell growth was decreased. Downregulation of DRR1 in NB39 cells inhibited low serum induced cell differentiation. The result of RT-PCR showed that the expression of DRR1 increased after differentiation induction in tumor sphere. In primary cultured hippocampal neurons, DRR1 located in both dendrite and axon. And after downregulation of DRR1 in hippocampal neuron, the length of neurite was decreased when compared to control. These results showed the possibility that DRR1 affect neuroblastoma cell growth by regulating cell's differentiation.
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