2011 Fiscal Year Final Research Report
Inhibition of RANK ligand-induced osteoclast differentiation by Porphyromonas gingivalis
| Project/Area Number |
22890115
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
NAKAYAMA Masaaki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10579105)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 歯周病原細菌 / Porphyromonas gingivalis / 破骨細胞分化 / 自然免疫 |
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| Research Abstract |
In this study, we demonstrated whether P. gingivalis affects osteoclastogenesis induced by RANK/RANKL signaling. Osteoclastic precursor cells were challenged by P. gingivalis with RANKL at the same time, analyzed its differentiation for matured osteoclasts. Interestingly, the osteoclastic precursors were inhibited RANK/RANKL-induced osteoclastogenesis by infection of P. gingivalis. It was, however, contratory to my expectation that osteoclasts were promoted to form the large number of matured cells and activated bone resorption by P. gingivalis infection. According to investigate this inhibition by using precursor cells from knockout mice of TLRs and adaptor factors, MyD88 and TRIF, it revealed that innate immune response through TLR2/MyD88 signaling pathway were related with this inhibition.
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Author(s)
Yujiro Nakashima, Hajime Isomoto, Kayoko Matsushima, Akira Yoshida, Toshiyuki Nakayama, Masaaki Nakayama, Junzo Hisatsune, Tatsuki Ichikawa, Fuminaoa Takeshima, TomayoshiHayashi, Kazuhiko Nakao, Toshiya Hirayama, and Shigeru Kohno
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Journal Title
Digestive Diseases and Sciences
Volume: 56(10)
Pages: 2887-2894
Peer Reviewed
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Author(s)
Ayako Matsumoto, Hajime Isomoto, Masaaki Nakayama, Junzo Hisatsune, Yoshito Nishi, Yujiro Nakashima, Kayoko Matsushima, Hisao Kurazono, Kazuhiko Nakao, Toshiya Hirayama, and Shigeru Kohno
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Journal Title
Digestive Diseases and Sciences
Volume: 56(4)
Pages: 999-1006
Peer Reviewed
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[Presentation] Streptomycin依存性結核菌における遺伝子変異の解明とStreptomycin耐性を誘導する新たな遺伝子変異2011
Author(s)
佐藤法仁, 阿戸学, 松村隆之, 山崎利雄, 関塚剛史, 黒田誠, 中山真彰, 井上哲圭, 本田尚子, 土田耕三, 小林和夫, 大原直也
Organizer
第64回日本細菌学会中国・四国支部総会口頭発表
Place of Presentation
岡山大学大学院自然科学研究科棟2階(岡山大学津島キャンパス)
Year and Date
20111022-23
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[Presentation] IDENTIFICATION OF THE NOVEL MUTATIONS IN 16S RRNA GENE OF THE SUBSTRAINS OF A STREPTOMYCINDEPENDENT MYCOBACTERIUM TUBERCULOSIS STRAIN18B WHICH CONFER STREPTOMYCIN RESISTANCE IN MYCOBACTERIUM2011
Author(s)
Norito Satoh, Manabu Ato, Takayuki Matsumura, Toshio Yamazaki, Tsuyoshi Sekizuka, Makoto Kuroda, Naoko Honda, Masaaki Nakayama, Kozo Tsuchida, Kazuo Kobayashi, Naoya Ohara
Organizer
International Union of Microbiological Societies(IUMS) Congress 2011 & 第84回日本細菌学会総会(ポスター発表)
Place of Presentation
北海道・札幌札幌コンベンションセンター
Year and Date
20110907-10
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