2011 Fiscal Year Final Research Report

The molecular biological analysis of the mechanism for cell adhesion mediated by growth factor in human gingival epithelial cells

Research Project

Project/Area Number	22890119
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Periodontal dentistry
Research Institution	Okayama University
Principal Investigator	YAMASHIRO Keisuke 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30581087)
Research Collaborator	YAMAMOTO Tadashi 岡山大学, 病院, 講師 (50432662) TAKASHIBA Shogo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
Project Period (FY)	2010 – 2011
Keywords	歯肉上皮細胞 / TGF-β / インテグリン / 細胞外基質 / Smad2 / Aggregatibacter actinomycetemcomitans
Research Abstract	Periodontal disease, chronic inflammation disease, is caused by infection of periodontal pathogen. It is thought that about 80% of Japanese are affected and it is a major cause of tooth loss. It is still unknown that the difference of progression of periodontal disease for each patient. It is thought that the attachment between gingival epithelial cells and tooth is a physical barrier from infection, and this attachment is important for prevention of periodontal disease. In this study, we hypothesis that growth factors secretes from gingival epithelial cells regulate the attachment between gingival epithelial cells and tooth, and we investigate the mechanism about the regulation.