2011 Fiscal Year Final Research Report
An experimental studies of degenerative change of the articular cartilage induced by the joint immobilization and the effect of the joint motion
| Project/Area Number |
22890139
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 不動 / 関節軟骨 / 軟骨基質 / 退行性変化 / 持続的他動運動 |
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| Research Abstract |
In this study, we examined the degeneration of articular cartilage induced by joint immobilization and the effects of continuous passive motion(CPM) on cartilage degeneration. Immobilization resulted in thinning of the articular cartilage after two-week immobilization and loss of proteoglycan content after four-week immobilization. On the other hands, CPM applied for immobilization period rectified all degenerative changes induced by joints immobilization in the articular cartilage. Additionally, CPM inhibited the increase of Matrix metalloproteinases and the decrease of tissue inhibitor of metalloproteinase.
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