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2011 Fiscal Year Final Research Report

Molecular analyses and clinical application of a novel oncogene, SMYD2 in gastrointestinal cancers.

Research Project

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Project/Area Number 22890158
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

KOMATSU Shuhei  京都府立医科大学, 医学研究科, 助教 (40578978)

Project Period (FY) 2010 – 2011
Keywords分子生化学 / 分子標的 / 癌遺伝子
Research Abstract

Previously, we detected the novel cancer-related gene, SMYD2(SET and MYND domain-containing protein 2) as a novel amplification target of 1q32-41 in esophageal squamous cell carcinoma(Komatsu S et al. Carcinogenesis 2009). In this study, we demonstrated the molecular mechanisms and clinical significance of SMYD2 in gastrointestinal cancers, especially in gastric carcinoma.

  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (4 results) Presentation (1 results)

  • [Journal Article] Prognostic impact of circulating miR-21 and miR-375 in plasma of patients with esophageal squamous cell carcinoma2012

    • Author(s)
      Komatsu S, Ichikawa D, Otsuji E, et al
    • Journal Title

      Expert Opin Biol Ther

      Volume: 12 Pages: S53-9

    • DOI

      doi:10.1517/14712598.2012.681373

  • [Journal Article] Circulating microRNA in digestive tract cancers2012

    • Author(s)
      Ichikawa D, Komatsu S, Otsuji E, et al
    • Journal Title

      Gastroenterology

      Volume: 142 Pages: 1074-1078

    • DOI

      doi:10.1053/j.gastro.2012.03.008

  • [Journal Article] Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer2011

    • Author(s)
      Morimura R, Komatsu S, Ichikawa D, Otsuji E, et al
    • Journal Title

      Br J Cancer

      Volume: 22 Pages: 1733-40

    • DOI

      doi:10.1038/bjc.2011.453.

  • [Journal Article] Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma2011

    • Author(s)
      Komatsu S, Ichikawa D, Otsuji E, et al
    • Journal Title

      Br J Cancer

      Volume: 105 Pages: 104-11

    • DOI

      doi:10.1038/bjc.2011.198.

  • [Presentation] 食道癌扁平上皮癌の増幅領域の再評価により同定した新しい癌関連遺伝子SMYD2の癌化機構の解明と臨床応用2010

    • Organizer
      日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-08

URL: 

Published: 2013-07-31  

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