2011 Fiscal Year Final Research Report
Molecular analyses and clinical application of a novel oncogene, SMYD2 in gastrointestinal cancers.
| Project/Area Number |
22890158
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KOMATSU Shuhei 京都府立医科大学, 医学研究科, 助教 (40578978)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 分子生化学 / 分子標的 / 癌遺伝子 |
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| Research Abstract |
Previously, we detected the novel cancer-related gene, SMYD2(SET and MYND domain-containing protein 2) as a novel amplification target of 1q32-41 in esophageal squamous cell carcinoma(Komatsu S et al. Carcinogenesis 2009). In this study, we demonstrated the molecular mechanisms and clinical significance of SMYD2 in gastrointestinal cancers, especially in gastric carcinoma.
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