2011 Fiscal Year Final Research Report
Evaluation of radiation-induced tumor cell alterations using manganese enhanced MRI
| Project/Area Number |
22890240
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Osaka University (2011)
National Institute of Radiological Sciences (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 放射線治療 / マンガン造影MRI / 動物MRI / 腫瘍マウス / 細胞周期 / 細胞増殖能 |
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| Research Abstract |
The purpose of radiotherapy is to treat malignancies with the intention of destroying or inactivating cells. It is important to detect an early response of radiotherapy against tumor cells. We conducted the manganese-enhanced MRI(MEMRI) to detect radiation-induced cell cycle arrest. Mn^<2+> accumulation is decreased in radiation-exposed in-vitro/ vivo tumor cells with the cell cycle arrest. Our data provide evidence that MEMRI become a more specific in-vitro/ vivo tumor imaging of cell cycle alterations.
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