2011 Fiscal Year Final Research Report

Molecular mechanism of differentiation of neural crest and neuroblastoma cells regulated by p53 family member

Research Project

Project/Area Number	22890242
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Pediatric surgery
Research Institution	Osaka University
Principal Investigator	FUJITANI Masashi 大阪大学, 連合小児発達学研究科, 助教 (40376372)
Project Period (FY)	2010 – 2011
Keywords	神経芽腫 / p53 / 発生分化
Research Abstract	Neuroblastoma is a pediatric tumor originated from the sympathetic nervous system and is thought to originate from a differentiation arrest of the neural crest. I have tried to establish the method to determine neural crest cells fate applied with in utero electroporation technique, but injection into neural tube was technically unfeasible to achieve, therefore I could not achieve to track neural crest cell differentiation status with reproducible results.