2011 Fiscal Year Final Research Report
Development of novel vaccine against tuberculosis using recombinant BCG expressing SOCS1 antagonist
| Project/Area Number |
22890255
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | 独立行政法人医薬基盤研究所 |
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Principal Investigator |
WATANABE Kenta 独立行政法人医薬基盤研究所, 霊長類医科学研究センター, 研究員 (20582208)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUO Kazuhiro 日本BCG研究所, 研究開発部, 研究開発部長 (70521095)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 結核ワクチン / BCG / SOCS1 |
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| Research Abstract |
I developed novel vaccine against tuberculosis using recombinant BCG expressing dominant negative of SOCS1(rSOCS-DN/BCG), and evaluated the effectiveness in mice. rSOCS-DN/BCG immunization elicited Mycobacterium antigen specific immune responses. Furthermore the immunization with rSOCS-DN/BCG showed significant protection against tuberculosis in mice. These results indicated further evidences for the possibility of rSOCS-DN/BCG as a novel vaccine against tuberculosis.
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