2023 Fiscal Year Final Research Report
Construction of metal complex assemblies using DNA-template and the application for functional films
| Project/Area Number |
22K14695
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 34010:Inorganic/coordination chemistry-related
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| Research Institution | Josai University |
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Principal Investigator |
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| Project Period (FY) |
2022-04-01 – 2024-03-31
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| Keywords | 金属錯体 / DNA / 自己集合 / ナノ材料 |
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| Outline of Final Research Achievements |
In this study, we synthesized salen-type platinum(II) and zinc(II) complexes with thymine(T) substituent, and hybridized them with adenine(A) oligomers.
We successfully arranged the complex molecules by A-T interaction. Oligomers consisting of five adenine molecules (A-5mer) had low structural stability and could not be formed the interactions.
On the other hand, A-10mer and A-15mer showed absorption spectral changes depending on the number of complex molecules, suggesting that they were quantitatively aligned through A-T interactions. In other words, the nucleobase incorporation succeeded in the accumulation of metal complex molecules with a precisely controlled number of molecules. In the future, we will produce the thin films by compositing of the metal complex-DNA assembly with lipids.
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| Free Research Field |
錯体化学、無機化学、生物無機化学
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| Academic Significance and Societal Importance of the Research Achievements |
従来、分子性金属錯体の集積化は有機溶媒や錯体濃度、その他様々な条件に起因するため次元性・配向性の制御が困難であった。本手法は、核酸塩基の導入のみが分子集積制御の鍵となっており金属錯体種に寄らないことから、あらゆる錯体分子に対応した新しい錯体分子集積化法を確立することができる。また、鋳型となるDNA鎖は塩基配列を自在に組み替えることができ、複数の金属錯体に異なる核酸塩基を導入することで異種錯体の混合配列も可能となる。すなわち、異なる機能を持つ金属錯体の複合化による多機能性材料の開発も可能となり、新たな機能性ナノ物質化学を開拓することができる。
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