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2023 Fiscal Year Final Research Report

Thermalphysiology of cardiac contractile regulation using diamond quantum sensors

Research Project

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Project/Area Number 22K15367
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 48020:Physiology-related
Research InstitutionNational Institutes for Quantum Science and Technology

Principal Investigator

Ishii Shuya  国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 量子機能創製研究センター, 研究員 (10880651)

Project Period (FY) 2022-04-01 – 2024-03-31
Keywords筋肉 / 体温 / 骨格筋 / 筋収縮 / 温度センサー
Outline of Final Research Achievements

The muscle contraction systems of skeletal and cardiac muscles were reconstituted using purified proteins, and their heat response, or temperature sensitivity, was evaluated. The results showed that there is a difference in the temperature at which regulatory proteins are activated between skeletal and cardiac muscles, and that the skeletal muscle contraction system is more sensitive to temperature increases near body temperature than the cardiac muscle. Unlike the heart, which is constantly beating, it was suggested that skeletal muscles have a function that is suitable for instantly generating force when needed. The research results were submitted and published in an international academic journal, and a press release was also issued together with the collaborative research institute.

Free Research Field

生物物理学

Academic Significance and Societal Importance of the Research Achievements

本研究では、骨格筋の筋収縮における体温の役割を明らかにした。特に運動前のウォーミングアップによって、筋肉を予め活性化することでパフォーマンスを高めていると考えることができる。
筋肉収縮により産生された熱が環境へ散逸する過程では、体温が上昇するだけでなく、筋収縮システムそのものに影響し、その働きを補助したり、制御しているのではないかという仮説を立て、これを実験的に検証した。これまでCa2+シグナルに基づいた医療機器開発や筋トレーニング・リハビリテーションの技術開発が進んできたように、本成果は温度シグナルに基づいた新しい温熱療法、健康医療のための技術開発の扉を開くことが期待される。

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Published: 2025-01-30  

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