Elucidation of the progression mechanisms of invasive mucinous adenocarcinoma and identification of novel therapeutic targets

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K15416
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Juntendo University
• Principal Investigator: Kishikawa Satsuki 順天堂大学, 医学部, 非常勤助教 (10906598)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 浸潤性粘液性腺癌 / 肺癌 / IMA / エンハンサー・ゲノム転写ネットワーク / 転写開始点 / トランスクリプトーム

Outline of Final Research Achievements

Comprehensive analysis of the enhancer-genome transcriptional network of about 190 lung cancer cases, including invasive mucinous lung adenocarcinoma, revealed the existence of two clusters for each histological type, in addition to the formation of separate clusters for different histological types such as adenocarcinoma, squamous cell carcinoma, and small cell carcinoma. Invasive mucinous lung adenocarcinoma is included in the cluster of adenocarcinomas that includes many non-TRU adenocarcinomas, but further analysis and investigation will be conducted to further understand invasive mucinous lung adenocarcinoma. Derived from this study, we report results from an integrated analysis of CT imaging findings, genetic abnormalities, and mucin expression that support a stepwise progression from a nodular to a pneumonia-like morphology in invasive mucinous lung adenocarcinoma.

Free Research Field

肺癌

Academic Significance and Societal Importance of the Research Achievements

今までの網羅的遺伝子変異検索や免疫組織化学を用いたタンパク発現による理解に加え、今回のゲノム転写ネットワークの包括的理解を含むアプローチにより、浸潤性粘液性肺腺癌を含む肺癌の、より厚くかつ多面的な理解につながった。浸潤性粘液性肺腺癌はnon-TRU腺癌を多く含む腺癌のクラスターに含まれたが、さらなる解析を追加し、新規治療標的・バイオマーカーの同定に向けて検討をすすめる。