Correlation of clock genes with peripheral blood gene expression by treatment of sleep abnormalities in psychiatric disorders.

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K15765
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Ehime University
• Principal Investigator: Ozaki Yuuki 愛媛大学, 医学系研究科, 助教 (40769527)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 睡眠障害 / 血液 / 遺伝子発現 / 時計遺伝子 / 睡眠衛生指導

Outline of Final Research Achievements

We are checking how the expression of sleep genes in the peripheral blood changes before and after treatment of psychiatric disorders, focusing on depression severe enough to require inpatient treatment. They also use actigraphy to confirm how sleep status has changed.
Since it is difficult to collect data on patients with severe depression due to mental symptoms such as cessation of thinking, it is difficult to obtain consent for the study and data are difficult to collect.

Free Research Field

精神神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究において精神疾患患者の睡眠障害の実態と睡眠衛生指導の重要性を再確認できた。また血液の時計遺伝子の発現解析が可能で、アルツハイマー型認知症でCLOCK遺伝子の変化があることが確認できた。当初の予定にあったアクチグラフを用いた解析や統合失調症やうつ病など認知症以外の疾患における解析ができていないことから、これからも研究を継続する予定である。