2023 Fiscal Year Final Research Report
Gene Expression Analysis to Identify Factors Contributing to the High Malignancy of Morphea-like Basal Cell Carcinoma
Project/Area Number |
22K16286
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53050:Dermatology-related
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Research Institution | University of the Ryukyus |
Principal Investigator |
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Project Period (FY) |
2022-04-01 – 2024-03-31
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Keywords | 基底細胞癌 / 斑状強皮症型 / 結節型 / トランスクリプトーム解析 |
Outline of Final Research Achievements |
Transcriptome analysis using tumor tissues of morpheaform, nodular, and trichoepithelioma subtypes, as well as Caucasoid nodular subtypes of basal cell carcinoma, revealed characteristic gene family expression variations, particularly between morpheaform and nodular subtypes. These genes have been reported as tumor-associated antigens and are presumed to explain the differences in phenotype and prognosis between morpheaform and nodular subtypes. Additionally, it is expected that antibodies against proteins encoded by other differentially expressed genes will lead to the discovery of markers for histologically distinguishing these subtypes through immunostaining.
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Free Research Field |
皮膚科学関連
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Academic Significance and Societal Importance of the Research Achievements |
基底細胞癌の中でも斑状強皮症型は、他の結節型や表在型と比較し、外科的切除後の再発率や遠隔転移の発生率が高く予後不良である。本研究課題では、斑状強皮症型基底細胞癌の腫瘍浸潤性や転移能などの病態に重要な役割を果たすことが予測されるいくつかの遺伝子を見出した。これらの遺伝子は斑状強皮症型の高悪性度を理解するための糸口となると考えられる。斑状強皮症型の基底細胞癌の正確な鑑別は、患者の予後に大きく関わるため、免疫染色による組織学的な診断に用いるマーカーが求められる。今回の我々の見出した斑状強皮症型基底細胞癌に特異的に発現しているタンパク質がそれらのマーカーの候補となることが期待される。
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