The biomechanical effect of medial meniscal ramp lesion repair concomitant with anterior cruciate ligament reconstruction in a large animal model

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K16772
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56020:Orthopedics-related
• Research Institution: Jichi Medical University
• Principal Investigator: Takahashi Tsuneari 自治医科大学, 医学部, 講師 (80781301)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 膝関節 / 前十字靭帯損傷 / 大動物モデル / 生体力学的研究 / 組織学的研究

Outline of Final Research Achievements

Experiments were performed with the goal of evaluating whether untreated medial meniscus ramp lesions (MMRL) affect the postoperative biomechanical characteristics of tendon grafts in anterior cruciate ligament (ACL) reconstruction and to determine the histological findings of the medial meniscus (MM) in a porcine model. Untreated MMRL did not significantly affect anterior knee laxity or structural characteristics of the grafted tendon. In contrast, the UM group showed histological deterioration of the medial meniscus at 12 weeks postoperatively. The above summary was prepared as a paper and submitted to the Journal of Experimental Orthopaedics, an international journal in the field of orthopaedics, with an initial decision scheduled for acceptance after revision.

Free Research Field

整形外科学

Academic Significance and Societal Importance of the Research Achievements

未治療の内側半月板隆起病変(MMRL)が、前十字靭帯(ACL)再建術における腱移植片の術後生体力学的特性に影響を及ぼすかどうかを評価した初の大動物モデル研究であり、本研究の成果は膝前十字靭帯損傷に対する術後移植腱の力学的強度劣化が低減 された新規手術治療法の開発の基盤となると期待される。