Development of a novel therapy for deep dermal wounds - application of mesenchymal stem cell exosomes.

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K16993
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Hokkaido University
• Principal Investigator: Sato Chigusa 北海道大学, 医学研究院, 客員研究員 (70893767)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 羊膜由来幹細胞 / エクソソーム / マウス / 急性創傷 / 創傷治癒 / 熱傷

Outline of Final Research Achievements

Severe burns continue to have a high mortality rate, and burn surface area is a factor that significantly affects prognosis. The concept of burn wound conversion, in which burns progress, widen and deepen over time, has been the subject of basic research using animal models such as rats and pigs. In this study, we investigated the effects of amnion-derived mesenchymal stem cell exosomes on burn wounds in an animal model of burn wound conversion using mice. While administration of amnion-derived mesenchymal stem cell exosomes to wounds such as ulcers has been reported to promote wound healing, this study suggests that administration of amnion-derived mesenchymal stem cell exosomes may also inhibit burn wound conversion.

Free Research Field

形成外科

Academic Significance and Societal Importance of the Research Achievements

Burn wound conversionによる熱傷創の拡大・深達化を抑制することができれば、広範囲熱傷による生存率改善に貢献しうる。また本研究によりburn wound conversionの病態生理のさらなる解明に繋がる可能性がある。