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2023 Fiscal Year Final Research Report

The mechanism of progression of Multiple sclerosis by periodontitis associated bacteria

Research Project

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Project/Area Number 22K17011
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 57020:Oral pathobiological science-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Okano Tokuju  東京医科歯科大学, 大学院医歯学総合研究科, 助教 (70886663)

Project Period (FY) 2022-04-01 – 2024-03-31
Keywords歯周炎 / 多発性硬化症 / インフラマソーム
Outline of Final Research Achievements

Previous studies demonstrated that Porphyromonas gingivalis (P. gingivalis, Pg), periodontitis associated bacteria can exacerbates Multiple Sclerosis (MS) in clinical study. In this study we investigated ROS production and TRIF expression level controls inflammasome activation under hypoxic condition by RNA sequencing analysis of bone marrow derived macrophages (BMDMs). Actually ROS inhibitor suppress the inflammasome activation by Pg infection in BMDMs. We also checked TRIF deficient BMDMs infected with Pg under normoxia and hypoxia. Inflammasome activation is low level compared to wild-type BMDMs. These tendency is same as HIF-1α deficiency.

Free Research Field

口腔感染症

Academic Significance and Societal Importance of the Research Achievements

この研究成果は、長年議論されてきた歯周炎とMSに関する研究に大きなインパクトを与えることができる。また、増悪化メカニズムを理解することによって、歯周炎とMSを併発した患者さんのための新たな抗歯周炎-MS薬の開発へとつなげられることが予想される。さらに本研究は、多発性硬化症のみならす、歯科学において長年議論され続けている様々な歯周炎と自己免疫疾患、または歯周炎と全身疾患の連関メカニズムを解明する足掛かりとなっていくことが期待される。

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Published: 2025-01-30  

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