Investigation of mechanism in palate-nasal malformation

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K17248
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 57070:Developmental dentistry-related
• Research Institution: Niigata University
• Principal Investigator: Ichikawa Kaya 新潟大学, 医歯学系, 助教 (70846063)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 口唇裂・口蓋裂

Outline of Final Research Achievements

Cleft lip and palate are often associated with nasal deformities. Therefore, it is important to understand the mechanism of formation of nasal region, which has not been fully elucidated. This study suggests the possibility that primary cilia is involved in nasal septum development as a part of midline formation through regulating Hh signaling.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

口唇裂・口蓋裂は鼻部の変形などの異常を伴うことが多くある。近年、そのようなケースに対し、口唇裂・口蓋裂への治療の前に、鼻の矯正治療法（術前鼻歯槽形成、Presurgical NasoAlveolar Molding；PNAM）を行うことで、口唇裂・口蓋裂治療後の中顔面の審美性が向上するだけでなく、顎堤の正常な位置への誘導など、顔面・口腔内に様々な利点をもたらす事が報告されている。本研究成果は、その治療の向上などに大きく貢献できる。