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2022 Fiscal Year Research-status Report

母指球筋を用いた新たな筋量指標の開発と疾患予後を予測する指標への応用

Research Project

Project/Area Number 22K17576
Research InstitutionNiigata University of Health and Welfare

Principal Investigator

井上 達朗  新潟医療福祉大学, リハビリテーション学部, 講師 (40882303)

Project Period (FY) 2022-04-01 – 2026-03-31
Keywordsサルコペニア / 高齢者 / 骨格筋量 / 母指球 / 超音波画像診断装置
Outline of Annual Research Achievements

我々は,あらゆる病態におけるサルコペニア診断への応用を目的に「母指球筋」を新たな骨格筋量指標として着目して研究を開始した.当該年度は,研究①健常若年男性を対象としたMRI研究,研究②地域在住中高齢者を対象とした超音波研究を遂行することができた.
まず,研究①として,健常若年男性7名を対象に3テスラ高解像度MRIを用いて利き手の母指球筋の撮像を試みた.当初難渋すると予想された母指球筋撮像姿位や撮像条件を含むプロトコルの決定は,当初の予想を覆し極めて円滑にイメージングを達成することができた.得られた母指球筋の撮像画像から母指球筋容量を算出し,全身の骨格筋量として算出した大腿筋容量との相関関係を解析した結果,高い相関関係を示すことを確認した.その後,超音波画像診断装置を使用して,MRIで撮像した母指球筋容量を最も反映する筋厚計測部位を決定し,母指球筋厚(mm)と定義した.超音波画像診断装置で計測した母指球筋厚は,MRIで撮像した母指球筋容量と大腿筋容量と有意に相関することを確認した.
次に,研究②として,新潟県佐渡市在住の40歳以上の地域在住中高齢男性63名を対象として,開発した母指球筋厚の妥当性を検討した.外的妥当性を分析するために生体電気インピーダンス法で測定した四肢骨格筋量を用いた.その結果,母指球筋厚と四肢骨格筋量は有意な相関を示し,母指球筋指標が全身の骨格筋量を反映す新たなマーカーとなる可能性が示唆された.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

当初難渋すると予想されたMRIでの母指球筋撮像のプロトコルの決定は,予備実験を数回実施することで,当初の予想を覆し極めて円滑に進めることができた.画像処理も円滑に進めることができ,母指球筋容量が全身の骨格筋量指標を反映するマーカーとなる可能性を見出すことができた.臨床応用へ繋げるために,地域住民での妥当性検証も進められている.

Strategy for Future Research Activity

現段階では,母指球筋が全身の筋量を反映するかについては,男性のみのデータ収集に留まっている.今後は,女性のデータを収集する必要がある.加えて,これまで正確な筋量測定が困難とされてきた下肢骨折の外科的治療後や下肢・体幹に浮腫を有する内部障害患者,全身に各種デバイスが接続された重症患者における妥当性を検証する必要がある.

  • Research Products

    (34 results)

All 2023 2022 Other

All Int'l Joint Research (1 results) Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 7 results) Presentation (13 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Remarks (1 results)

  • [Int'l Joint Research] シャリテ・ベルリン医科大学/University College Cork(ドイツ)

    • Country Name
      GERMANY
    • Counterpart Institution
      シャリテ・ベルリン医科大学/University College Cork
  • [Journal Article] Exploring biomarkers of osteosarcopenia in older adults attending a frailty clinic2023

    • Author(s)
      Inoue Tatsuro、Shimizu Akio、Murotani Kenta、Satake Shosuke、Matsui Yasumoto、Arai Hidenori、Maeda Keisuke
    • Journal Title

      Experimental Gerontology

      Volume: 172 Pages: 112047~112047

    • DOI

      10.1016/j.exger.2022.112047

    • Peer Reviewed / Open Access
  • [Journal Article] Impact of sarcopenic obesity on functional outcomes2023

    • Author(s)
      Shimizu Akio、Inoue Tatsuro、Maeda Keisuke
    • Journal Title

      Aging

      Volume: - Pages: -

    • DOI

      10.18632/aging.204549

    • Peer Reviewed
  • [Journal Article] Impact of postoperative physical activity on the development of pneumonia in the subacute phase after esophagectomy in patients with esophageal cancer: A retrospective cohort study2023

    • Author(s)
      Kondo Shin、Inoue Tatsuro、Saito Takashi、Fujikawa Takashi、Kamada Motomu、Inoue Seiya、Fujiwara Satoshi、Goto Masakazu、Sato Nori、Ono Rei、Akisue Toshihiro、Katoh Shinsuke、Takizawa Hiromitsu、Matsuura Tetsuya
    • Journal Title

      European Journal of Oncology Nursing

      Volume: 62 Pages: 102270~102270

    • DOI

      10.1016/j.ejon.2023.102270

    • Peer Reviewed
  • [Journal Article] Malnutrition on admission is associated with trunk function recovery but not with lower limb muscle strength recovery in patients with acute stroke: an observational cohort study2023

    • Author(s)
      Nozoe Masafumi、Inoue Tatsuro、Ishida Mitsuru、Yamamoto Kenta、Kanai Masashi
    • Journal Title

      Nutrition

      Volume: 109 Pages: 111971~111971

    • DOI

      10.1016/j.nut.2023.111971

    • Peer Reviewed
  • [Journal Article] Trajectories of the Prevalence of Sarcopenia in the Pre- and Post-Stroke Periods: A Systematic Review2022

    • Author(s)
      Inoue Tatsuro、Ueshima Junko、Kawase Fumiya、Kobayashi Haruko、Nagano Ayano、Murotani Kenta、Saino Yoko、Maeda Keisuke
    • Journal Title

      Nutrients

      Volume: 15 Pages: 113~113

    • DOI

      10.3390/nu15010113

    • Peer Reviewed / Open Access
  • [Journal Article] Diet-induced inflammation is associated with sarcopenia and muscle strength in older adults who visit a frailty clinic2022

    • Author(s)
      Inoue Tatsuro、Shimizu Akio、Ueshima Junko、Murotani Kenta、Nagano Ayano、Ishida Yuria、Kinoshita Kaori、Iizuka Yumiko、Satake Shosuke、Matsui Yasumoto、Arai Hidenori、Maeda Keisuke
    • Journal Title

      Aging Clinical and Experimental Research

      Volume: 34 Pages: 2525~2532

    • DOI

      10.1007/s40520-022-02195-9

    • Peer Reviewed
  • [Journal Article] Predictive Value of Temporal Muscle Thickness for Sarcopenia after Acute Stroke in Older Patients2022

    • Author(s)
      Nagano Ayano、Shimizu Akio、Maeda Keisuke、Ueshima Junko、Inoue Tatsuro、Murotani Kenta、Ishida Yuria、Mori Naoharu
    • Journal Title

      Nutrients

      Volume: 14 Pages: 5048~5048

    • DOI

      10.3390/nu14235048

    • Peer Reviewed / Open Access
  • [Journal Article] Early physical rehabilitation effectiveness in frail older patients hospitalized for community-acquired pneumonia: analysis of a nationwide database in Japan2022

    • Author(s)
      Shimizu Akio、Maeda Keisuke、Inoue Tatsuro、Mori Naoharu、Momosaki Ryo
    • Journal Title

      Aging Clinical and Experimental Research

      Volume: 35 Pages: 341~348

    • DOI

      10.1007/s40520-022-02302-w

    • Peer Reviewed
  • [Journal Article] Rehabilitation Nutrition in Patients with Chronic Kidney Disease and Cachexia2022

    • Author(s)
      Okamura Masatsugu、Inoue Tatsuro、Ogawa Masato、Shirado Kengo、Shirai Nobuyuki、Yagi Takuma、Momosaki Ryo、Kokura Yoji
    • Journal Title

      Nutrients

      Volume: 14 Pages: 4722~4722

    • DOI

      10.3390/nu14224722

    • Peer Reviewed / Open Access
  • [Journal Article] The impacts of preoperative frailty on readmission after cardiac implantable electrical device implantation2022

    • Author(s)
      Takeda Tomonori、Tsubaki Atsuhiro、Ikeda Yoshifumi、Kato Ritsushi、Hotta Kazuki、Inoue Tatsuro、Kojima Sho、Kanai Risa、Terazaki Yoshitaka、Uchida Ryusei、Makita Shigeru
    • Journal Title

      PLOS ONE

      Volume: 17 Pages: -

    • DOI

      10.1371/journal.pone.0277115

    • Peer Reviewed / Open Access
  • [Journal Article] Impact of sarcopenia defined by carina-level skeletal muscle mass on the long-term prognosis of patients with idiopathic pulmonary fibrosis2022

    • Author(s)
      Fujikawa Takashi、Kondo Shin、Saito Takashi、Inoue Tatsuro、Otake Kohei、Misu Shogo、Sakai Hideki、Ono Rei、Tomioka Hiromi
    • Journal Title

      Respiratory Medicine and Research

      Volume: 82 Pages: 100965~100965

    • DOI

      10.1016/j.resmer.2022.100965

    • Peer Reviewed
  • [Journal Article] Prevalence of sarcopenic obesity based on newly proposed diagnostic criteria and functional outcomes in older adults undergoing rehabilitation2022

    • Author(s)
      Shimizu Akio、Maeda Keisuke、Ueshima Junko、Inoue Tatsuro、Murotani Kenta、Ohno Tomohisa、Nomoto Akiko、Nagano Ayano、Kayashita Jun、Mori Naoharu、Fujishima Ichiro
    • Journal Title

      Mechanisms of Ageing and Development

      Volume: 208 Pages: 111728~111728

    • DOI

      10.1016/j.mad.2022.111728

    • Peer Reviewed
  • [Journal Article] Relationship between Nutrition-Related Problems and Falls in Hemodialysis Patients: A Narrative Review2022

    • Author(s)
      Shirai Nobuyuki、Inoue Tatsuro、Ogawa Masato、Okamura Masatsugu、Morishita Shinichiro、Suguru Yamamoto、Tsubaki Atsuhiro
    • Journal Title

      Nutrients

      Volume: 14 Pages: 3225~3225

    • DOI

      10.3390/nu14153225

    • Peer Reviewed / Open Access
  • [Journal Article] Malnutrition diagnosed by the Global Leadership Initiative on Malnutrition criteria as a predictor of gait ability in patients with hip fracture2022

    • Author(s)
      Kobayashi Hikaru、Inoue Tatsuro、Ogawa Masato、Abe Takafumi、Tanaka Toshiaki、Kakiuchi Masayoshi
    • Journal Title

      Injury

      Volume: 53 Pages: 3394~3400

    • DOI

      10.1016/j.injury.2022.08.004

    • Peer Reviewed / Open Access
  • [Journal Article] Effect of tongue strength on clinical outcomes of patients: A systematic review2022

    • Author(s)
      Nagano Ayano、Ueshima Junko、Tsutsumiuchi Keita、Inoue Tatsuro、Shimizu Akio、Mori Naoharu、Maeda Keisuke
    • Journal Title

      Archives of Gerontology and Geriatrics

      Volume: 102 Pages: 104749~104749

    • DOI

      10.1016/j.archger.2022.104749

    • Peer Reviewed
  • [Journal Article] Allogeneic haematopoietic stem cell transplantation and patient falls: impact of lower extremity muscle strength2022

    • Author(s)
      Kondo Shin、Inoue Tatsuro、Saito Takashi、Kawamura Yuka、Katayama Ayane、Nakamura Masafumi、Sumitani Ryohei、Takahashi Mamiko、Oura Masahiro、Sogabe Kimiko、Harada Takeshi、Fujii Shiro、Nakamura Shingen、Miki Hirokazu、Kagawa Kumiko、Sato Nori、Ono Rei、Abe Masahiro、Katoh Shinsuke
    • Journal Title

      BMJ Supportive and Palliative Care

      Volume: - Pages: -

    • DOI

      10.1136/bmjspcare-2022-003582

    • Peer Reviewed
  • [Journal Article] Decreased Diversity of Gut Microbiota Is Associated with Decreased Muscle Mass and Function in Older Adults Residing in a Nursing Home2022

    • Author(s)
      Ishida Y.、Maeda Keisuke、Inoue T.、Satake S.、Mori N.
    • Journal Title

      The journal of nutrition, health and aging

      Volume: 26 Pages: 537~538

    • DOI

      10.1007/s12603-022-1792-x

    • Peer Reviewed
  • [Journal Article] Association between food texture levels consumed and the prevalence of malnutrition and sarcopenia in older patients after stroke2022

    • Author(s)
      Shimizu Akio、Fujishima Ichiro、Maeda Keisuke、Murotani Kenta、Ohno Tomohisa、Nomoto Akiko、Nagami Shinsuke、Nagano Ayano、Sato Keisuke、Ueshima Junko、Inoue Tatsuro、Shimizu Midori、Ishida Yuria、Kayashita Jun、Suenaga Masaki、Mori Naoharu
    • Journal Title

      European Journal of Clinical Nutrition

      Volume: 76 Pages: 1576~1582

    • DOI

      10.1038/s41430-022-01126-1

    • Peer Reviewed
  • [Journal Article] The safety of exercise for older patients with severe aortic stenosis undergoing conservative management: A narrative review2022

    • Author(s)
      Nashimoto Satoshi、Inoue Tatsuro、Hotta Kazuki、Sugito Yuichi、Iida Susumu、Tsubaki Atsuhiro
    • Journal Title

      Physiological Reports

      Volume: 10 Pages: -

    • DOI

      10.14814/phy2.15272

    • Peer Reviewed
  • [Presentation] Diet-induced inflammation increases the likelihood of sarcopenia in older adults2022

    • Author(s)
      Inoue T, Shimizu A, Ueshima J, Murotani K, Nagano A, Ishida Y, Kinoshita K, Iizuka Y, Satake S, Matsui Y, Arai H, Maeda K.
    • Organizer
      The 22nd World Congress of Gerontology and Geriatrics
    • Int'l Joint Research
  • [Presentation] Osteosarcopenia increases the likelihood of cognitive frailty compared to osteoporosis and sarcopenia in older outpatients visiting a frailty clinic2022

    • Author(s)
      Inoue T, Maeda K, Satake S, Matsui Y, Arai H
    • Organizer
      The 22nd World Congress of Gerontology and Geriatrics
    • Int'l Joint Research
  • [Presentation] 栄養と理学療法のインタラクション2022

    • Author(s)
      井上達朗
    • Organizer
      第8回日本栄養・嚥下理学療法学会学術大会
    • Invited
  • [Presentation] Sarcopenia and Physical rehabilitation: Nutritional physical therapy for sarcopenia2022

    • Author(s)
      Inoue T
    • Organizer
      第12回日本リハビリテーション学会学術集会
    • Invited
  • [Presentation] オステオサルコペニアの基礎と研究の動向2022

    • Author(s)
      井上達朗
    • Organizer
      第12回日本リハビリテーション学会学術集会
    • Invited
  • [Presentation] 臨床研究のスモールスタート2022

    • Author(s)
      井上達朗
    • Organizer
      第12回日本リハビリテーション学会学術集会
    • Invited
  • [Presentation] 医療機関でのサルコペニアに対するエビデンスと栄養理学療法の役割2022

    • Author(s)
      井上達朗
    • Organizer
      第41回関東甲信越ブロック理学療法士学会
    • Invited
  • [Presentation] オステオサルコペニアのバイオマーカーの探索2022

    • Author(s)
      井上達朗, 清水昭雄, 室谷健太, 佐竹昭介, 松井康素, 荒井秀典, 前田圭介
    • Organizer
      第1回日本老年療法学会学術大会
  • [Presentation] オステオサルコペニアと認知的フレイルは関連する2022

    • Author(s)
      井上達朗, 清水昭雄, 佐竹昭介, 松井康素, 上島順子, 室谷健太, 荒井秀典, 前田圭介
    • Organizer
      第64回日本老年医学会学術集会
  • [Presentation] Cancer Cachexia and Clinical Outcomes in Palliative Care Older Patients according to CSS Classification2022

    • Author(s)
      Ueshima J, Maeda K, Shimizu A, Nagano A, Ishida Y, Takeuchi T, Nonogaki T, Matsuyama R, Inoue T, Mori N.
    • Organizer
      The 22nd World Congress of Gerontology and Geriatric
    • Int'l Joint Research
  • [Presentation] Correlation between tongue strength and clinical outcomes in medical patients: A systematic review2022

    • Author(s)
      Nagano A, Ueshima J, Tsutsumiuchi K, Inoue T, Shimizu A, Mori N, Maeda K.
    • Organizer
      The 22nd World Congress of Gerontology and Geriatrics
    • Int'l Joint Research
  • [Presentation] 特発性正常圧水頭症における髄液排除試験前後およびシャント術後の脳内酸素動態の変化2022

    • Author(s)
      内山祈,齋藤寛代,小澤祐治,平田萌々花,長田きらら,小澤哲也,佐藤隆一,椿 淳裕,井上達朗,鈴木良介,霜田直史
    • Organizer
      第130回理学療法科学学会学術大会
  • [Presentation] SDOC 基準のサルコペニアは低ADL および抑うつ状態と関連する2022

    • Author(s)
      清水昭雄, 井上達朗, 佐竹昭介, 松井康素, 上島順子, 室谷健太, 荒井秀典
    • Organizer
      第64回日本老年医学会学術集会
  • [Remarks] OFS

    • URL

      https://osf.io/r4yt6/

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Published: 2023-12-25  

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