Preventing osteoarthritis after anterior cruciate ligament reconstruction by controlling weight bearing

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K17625
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Hiroshima International University
• Principal Investigator: Kaneguchi Akinori 広島国際大学, 総合リハビリテーション学部, 講師 (10826704)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 前十字靭帯再建 / 変形性膝関節症 / リハビリテーション / 荷重

Outline of Final Research Achievements

This study aimed to determine the effect of the amount of weight bearing on articular cartilage degeneration after anterior cruciate ligament reconstruction using a rat model.
After anterior cruciate ligament reconstruction, increase in weight bearing via pain relief by morphine administration had no effect on cartilage degeneration. On the other hand, cartilage degeneration was exacerbated by non-weight bearing after anterior cruciate ligament reconstruction. The cartilage degeneration induced by non-weight bearing did not improve after reloading. Our results suggest that early weight bearing after anterior cruciate ligament reconstruction is important to reduce cartilage degeneration.

Free Research Field

リハビリテーション

Academic Significance and Societal Importance of the Research Achievements

前十字靭帯再建後のリハビリテーションにおける適切な荷重量について、コンセンサスは得られていない。本研究では、前十字靭帯再建後の荷重量の違いが関節軟骨の変性に及ぼす影響を明らかにした。本研究の結果は、より良い前十字靭帯再建後のリハビリテーションプロトコル確立につながる重要な基礎データとなるであろう。