Characterization of the allergic herbaceous pollen reacted with air pollutants and health risk

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K18040
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 64010:Environmental load and risk assessment-related
• Research Institution: Saitama University
• Principal Investigator: WANG WEIQIAN 埼玉大学, 理工学研究科, 助教 (20897631)
• Project Period (FY): 2022-04-01 – 2024-03-31
• Keywords: 花粉 / 花粉アレルゲン / バイオエアロゾル

Outline of Final Research Achievements

In this study, the scattering behavior of herbaceous pollen and pollen allergens in the Kanto area were investigated. And it could get some influence by meteorological factors (temperature, etc.) Otherwise, the interaction between pollen and air pollutants were studied and investigated their effects on allergenic properties. The model-exposure experiments between cedar pollen grains and typical air pollutants. It has confirmed that ionic components could promote the rupture of cedar pollen grains. Moreover, an executive Caspase-3 activity sensing sensor (FRET type bioprobe) was tried to import into model cells (dermal cell NIH3T3 and cervical cancer cell HeLa) via exposed air pollutants and confirmed their potentially induce apoptosis.

Free Research Field

環境化学　大気環境

Academic Significance and Societal Importance of the Research Achievements

本研究は関東地区大気中の草本類花粉とアレルゲン物質の飛散挙動、汚染物質による花粉の構造変化やアレルギー性変更、細胞実験で汚染物質粒子等の健康リスクに着目した研究を行った。それらの人体への健康影響が懸念されている。今後、大気環境化学、バイオエアロゾルの事例研究、大気中の反応プロセス及び健康リスクを継続していく必要がある。