2023 Fiscal Year Final Research Report
Uncovering the pathogenesis of essential hypertension via mechanobiological approach
| Project/Area Number |
22K19761
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | National Rehabilitation Center for Persons with Disabilities |
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Principal Investigator |
Sawada Yasuhiro 国立障害者リハビリテーションセンター(研究所), 病院 臨床研究開発部(研究所併任), 臨床研究開発部長 (50313135)
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| Co-Investigator(Kenkyū-buntansha) |
高野 弘二 国立障害者リハビリテーションセンター(研究所), 研究所 脳機能系障害研究部, 研究員 (00510588)
齋藤 茂芳 大阪大学, 大学院医学系研究科, 准教授 (40583068)
崎谷 直義 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (30824859)
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| Project Period (FY) |
2022-06-30 – 2024-03-31
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| Keywords | メカニカルストレス / 高血圧 |
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| Outline of Final Research Achievements |
We conducted a comparative study between normotensive and hypertensive rats using a method where Dr. Saito captured MRI images of the brainstem morphology, which were subsequently analyzed by Dr. Takano employing AI techniques. We discovered that hypertensive rats exhibit a different angle between the long axis of the brainstem and that of the cerebral cortex compared to normotensive rats. The hypertensive induction experiments on normotensive rats, led by Dr. Sakitani from the National Cerebral and Cardiovascular Center, were unfortunately interrupted due to his relocation to the National Institute of Advanced Industrial Science and Technology.
Ultimately, we submitted a paper demonstrating hypertension improvement through mechanical stimulation to the head, which forms the basis of our study. After organizing and submitting the required data, we successfully published our findings in a high-impact international academic journal.
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| Free Research Field |
メカノバイオロジー
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| Academic Significance and Societal Importance of the Research Achievements |
肢体不自由障害者、一部の高齢者など、運動したくても運動できない者にも適用可能な簡便かつ日常使用可能な擬似運動刺激負荷装置の開発の基盤を形成することができた。極めて罹患者が多く、主要な死亡リスクファクターの一つでありながら、原因不明とされてきた本態性高血圧症の病態解明の端緒を築くことができた。これまで不明であった「運動の本体・正体」について明確に示すことができた。
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