Development of Stable Carbene Motifs that Bring out the Characteristic Properties of Group 16 Elements and Their Application to Synthetic Chemistry

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20541
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0501:Physical chemistry, functional solid state chemistry, organic chemistry, polymers, organic materials, biomolecular chemistry, and related fields
• Research Institution: Gakushuin University
• Principal Investigator: Masuda Ryosuke 学習院大学, 理学部, 助教 (30965794)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: カルコゲン / カルベン / セレン / 硫黄

Outline of Final Research Achievements

Carbenes are known as important chemical species in synthetic organic chemistry and their stabilization have been achieved by neighboring heteroatoms, e.g., nitrogen. However, Group 16 elements-stabilized carbenes have relatively underdeveloped. In this project, synthesis of Group 16 elements-stabilized carbenes by harnessing novel photoisomerization of chacogenocarbonyl main group compounds have been attempted. Consequently, the evidences for the generation of desired carbenes were not been obtained but the planned carbene precursors, a crystalline thioacylsilane and a thioacylgermane were isolated and crystallographically identified for the first time. The stabilities of such chalcogenocarbonyl compounds were also unveiled.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

医薬品合成や材料合成において重要な有機合成反応の多くは、稀少な遷移金属を核とする触媒に依存している。一方で、大きなクラーク数を有し安価な典型元素を利用した合成反応の開発は、比較的立ち遅れている。本研究では、資源豊富な16族および14族元素を有する新規化合物群を合成し、その性質を明らかにすることで、埋蔵量の少ない遷移金属依存の有機合成から脱却する1つの礎を築いたといえる。