Evaluation of sedation depth using a pulse oximeter

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21074
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Asahi University
• Principal Investigator: Hayashi Shintaro 朝日大学, 歯学部, 助教 (80966169)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 静脈内鎮静法 / パルスオキシメータ / Perfusion Index / Bispectral index / プロポフォール

Outline of Final Research Achievements

During intravenous sedation, sedation depth can be measured objectively using electroencephalography; however, the procedure is complicated and costly. Nevertheless, if a pulse oximeter, which is used to monitor intravenous sedation, can be used to evaluate sedation depth, it could become a clinically useful evaluation index. Thus, in this study, we evaluated sedation depth through the perfusion index (PI) measured by a pulse oximeter. The PI, bispectral index (BI), modified observer’s assessment of alertness/sedation score, SpO2, blood pressure, and pulse rate were measured. A correlation was observed between the PI and BI during intravenous sedation. Thus, sedation depth can be evaluated using the PI measured by a pulse oximeter.

Free Research Field

歯科麻酔学

Academic Significance and Societal Importance of the Research Achievements

静脈内鎮静法下で行われる歯科治療は過鎮静などによる致死的合併症が生じることから、適切な術中管理、つまりは鎮静深度のモニタリングを行う必要がある。鎮静深度の主観的評価には歯科麻酔科医の経験を要し、客観的評価は高額な機器・センサを使用する必要があり、その手段は限られている。本研究はパルスオキシメータと鎮静深度の関係性を明らかにし、静脈内鎮静法の客観的評価を行う新しいひとつの手法を示した。このことは、静脈内鎮静法の安全性を高めるとともに、歯科領域以外の鎮静法における鎮静深度評価に応用できる可能性を示した。