2022 Fiscal Year Research-status Report
Molecular epidemiology, antiviral resistant variants and therapeutic options of hepatitis B and C in Nigeria
Project/Area Number |
22KK0147
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Research Institution | Nagasaki University |
Principal Investigator |
吉田 レイミント 長崎大学, 熱帯医学研究所, 教授 (90432963)
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Co-Investigator(Kenkyū-buntansha) |
樋泉 道子 長崎大学, 熱帯医学研究所, 准教授 (00778623)
柳原 克紀 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40315239)
森内 浩幸 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90315234)
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Project Period (FY) |
2022-10-07 – 2025-03-31
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Keywords | Hepatitis B Virus / Hepatitis C Virus / Hepatitis D Virus / incidence / genotype / drug resistant variant / Nigeria |
Outline of Annual Research Achievements |
Necessary ethical approvals and Material Transfer Agreement have been obtained to conduct the study. A Nigeria PhD student, studying under the principal investigator at Nagasaki University visited Nigeria CDC to conduct the DNA extraction from 251 Hepatitis B positive samples and transported to Nagasaki University. The epidemiological information database of the viral hepatitis positive subjects has been obtained from Nigeria CDC.
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Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The necessary ethical approvals and MTA have been completed. The epidemiological data of the viral hepatitis survey and the first batch of HBV positive samples have been obtained. The data analysis and sample testing processes are progressing well as planed.
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Strategy for Future Research Activity |
2023 plan: The Japan research team plans to visit Nigeria CDC this year to discuss the ongoing data analysis and sample testing plan with the Nigeria CDC counterparts. Nucleic acid extraction of Hepatitis B Virus and Hepatitis C Virus samples will will be done. The samples will be transported to Nagasaki University for genotyping, drug resistant variant testing and whole genome sequencing analyses.
2024 plan: Further sample testing and data analysis will be done next year. The result of the study will be presented at domestic and international conference.
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Causes of Carryover |
This year's budget will include travel cost (1,500,000yen) for three researchers from Japan to visit Nigeria for 2 to 4 weeks. A personnel cost (1,000,000yen) for the sample processing and nucleic acid extract in Nigeria is also included. The remaining main portion of this year's budget will be used for sample testing reagents (PCR, next generation sequencing) and consumable cost in Japan.
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Research Products
(1 results)