2015 Fiscal Year Final Research Report
Molecular physiological study for the elucidation of mechanisms for modulation of neurotransmitter release
| Project/Area Number |
23220008
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011-04-01 – 2016-03-31
|
| Keywords | 神経科学 / 生理学 / 生体分子 / 脳・神経 / 遺伝子 |
|---|
| Outline of Final Research Achievements |
To elucidate the roles of functional molecules localized in the organelle in the presynaptic terminal, we examined synaptic transmission of gene-targeted mice lacking the molecules, and found that the mutant mice exhibited impaired presynaptic plasticity of excitatory synaptic transmission. We also examined the roles of presynaptic molecules interacting with the protein complex that regulated neurotransmitter release, and found that they are associated with the regulation of neurotransmitter release and the dynamics of synaptic vesicles in the presynaptic terminal. Furthermore, we found that some of the protein kinases present in the presynaptic terminal modified presynaptic short-term plasticity.
|
| Free Research Field |
神経生理学
|
