難治性心不全を克服するバイオニック自律神経制御システムの基盤研究

2015 Fiscal Year Annual Research Report

• Project/Area Number: 23220013
• Research Institution: Kyushu University
• Principal Investigator: 砂川 賢二 九州大学, 学内共同利用施設等, 研究員 (50163043)
• Co-Investigator(Kenkyū-buntansha): 岸 拓弥 九州大学, 学内共同利用施設等, 准教授 (70423514) ; 廣岡 良隆 九州大学, 学内共同利用施設等, 教授 (90284497) ; 井手 友美 九州大学, 医学(系)研究科(研究院), 講師 (90380625)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 自律神経制御 / 循環制御 / 心不全 / バイオニック

Outline of Annual Research Achievements

平成2６年度までの研究成果を受け、最終年度である平成2７年度はこれまでの要素技術を統合し、試作器を開発しその性能を動物実験で検証した。●制御論理の開発：圧反射が定常に達するには60秒程度かかる。このことは制御に際して60秒程度のインパルス応答（測定した血圧を圧反射求心路神経刺激に変換する）を実時間で畳み込み積分する必要がある。畳み込み積分は演算量が多く、植え込み型装置の消費電力が増え小型化に馴染まない。そこで、インパルス応答をパラメトリックにモデル化し、演算量の低減を試みた。その結果、演算量は1／100以下になることが示された。さらに近似モデルを利用することで、最終的には２つのパラメタ（参照信号とスケーラー）で代替できることが示された。●求心路が温存された部分圧反射不全動物モデルの作成：バイオニック圧反射を動作させるためには圧反射の求心路が残存している必要がある。求心路の神経を部分的に切断することで、求心路が温存された圧反射不全モデルの作成に成功した。部分圧反射不全動物の２４時間血圧のゆらぎは、正常群と完全圧反射不全の中間の値をとった。●バイオニック自律神経制御システムによる部分圧反射不全の治療：部分圧反射不全動物にバイオニック圧反射装置を装着した。その結果、制御パラメタを最適化することで、動脈圧のゆらぎは著明に低下し、ほぼ正常化した。●バイオニック自律神経制御システムによる圧反射不全の克服：圧反射不全モデル動物に対して、バイオニック自律神経制御システムを動作させることにより、生理的な圧反射を再構築することができた。同時に、血圧の安定化、容量耐性の改善等がもたらされ、心不全の治療に有効であることが示された。今後このモデルを用いることで、短期的、中長期的なバイオニック自律神経制御システムの治療効果を評価する。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] Haemodynamic unloading reverses occlusive vascular lesions in severe pulmonary hypertension. (2016)
  • Author(s): Abe K, Shinoda M, Tanaka M, Kuwabara Y, Yoshida K, Hirooka Y, McMurtry IF, Oka M, Sunagawa K.
  • Journal Title: Cardiovasc Res. Volume: In Press Pages: In Press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nonlinear Identification of the Total Baroreflex Arc: Chronic Hypertension Model. (2016)
  • Author(s): Moslehpour M, Kawada T, Sunagawa K, Sugimachi M, Mukkamala R.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. Volume: In Press Pages: In Press
  • DOI: 10.1152/ajpregu.00424.2015.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Translational Neurocardiology: preclinical models and cardioneural integrative aspects. (2016)
  • Author(s): Ardell JL, Andresen MC, Armour JA, Billman GE, Chen PS, Foreman RD, Herring N, O'Leary DS, Sabbah HN, Schultz HD, Sunagawa K, Zucker IH.
  • Journal Title: J Physiol. Volume: In Press Pages: In Press
  • DOI: 10.1113/JP271869.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Activation of microglia within paraventricular nucleus of hypothalamus is NOT involved in maintenance of established hypertension. (2016)
  • Author(s): Takesue K, Kishi T, Hirooka Y, Sunagawa K.
  • Journal Title: J Cardiol. Volume: In Press Pages: In Press
  • DOI: 10.1016/j.jjcc.2016.01.004.
  • Peer Reviewed
• [Journal Article] Total Mechanical Unloading Minimizes Metabolic Demand of Left Ventricle and Dramatically Reduces Infarct Size in Myocardial Infarction. (2016)
  • Author(s): Saku K, Kakino T, Arimura T, Sakamoto T, Nishikawa T, Sakamoto K, Ikeda M, Kishi T, Ide T, Sunagawa K.
  • Journal Title: PLoS One. Volume: 11 Pages: e0152911
  • DOI: 10.1371/journal.pone.0152911.
  • Peer Reviewed
• [Journal Article] Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function. (2016)
  • Author(s): Sakamoto K, Hosokawa K, Saku K, Sakamoto T, Tobushi T, Oga Y, Kishi T, Ide T, Sunagawa K.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 310 Pages: H199-H205
  • DOI: 10.1152/ajpheart.00610.2015.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload. (2015)
  • Author(s): Ikeda M, Ide T, Fujino T, Matsuo Y, Arai S, Saku K, Kakino T, Oga Y, Nishizaki A, Sunagawa K.
  • Journal Title: Sci Rep Volume: 5 Pages: 15881
  • DOI: 10.1038/srep15881.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nonlinear identification of the total baroreflex arc. (2015)
  • Author(s): Moslehpour M, Kawada T, Sunagawa K, Sugimachi M, Mukkamala R.
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 309 Pages: R1479-R1489
  • DOI: 10.1152/ajpregu.00278.2015.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Circulating angiotensin II deteriorates left ventricular function with sympathoexcitation via brain angiotensin II receptor. (2015)
  • Author(s): Shinohara K, Kishi T, Hirooka Y, Sunagawa K.
  • Journal Title: Physiol Rep. Volume: 3 Pages: e12514
  • DOI: 10.14814/phy2.12514.
  • Peer Reviewed
• [Journal Article] Brain Angiotensin II Type 1 Receptor Blockade Improves Dairy Blood Pressure Variability via Sympathoinhibition in Hypertensive Rats (2015)
  • Author(s): Kishi T, Hirooka Y, Sunagawa K.
  • Journal Title: Int J Hypertens. Volume: 2015 Pages: 759629
  • DOI: 10.1155/2015/759629.
  • Peer Reviewed
• [Journal Article] Decreased proportion of Foxp3+ CD4+ regulatory T cells contributes to the development of hypertension in genetically hypertensive rats. (2015)
  • Author(s): Katsuki M, Hirooka Y, Kishi T, Sunagawa K.
  • Journal Title: J Hypertens. Volume: 33 Pages: 773-783
  • DOI: 10.1097/HJH.0000000000000469.
  • Peer Reviewed
• [Journal Article] Prediction of the impact of venoarterial extracorporeal membrane oxygenation on hemodynamics. (2015)
  • Author(s): Sakamoto K, Saku K, Kishi T, Kakino T, Tanaka A, Sakamoto T, Ide T, Sunagawa K.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 308 Pages: H921-H930
  • DOI: 10.1152/ajpheart.00603.2014.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Calorie restriction improves cognitive decline via up-regulation of brain-derived neurotrophic factor: tropomyosin-related kinase B in hippocampus ofobesity-induced hypertensive rats. (2015)
  • Author(s): Kishi T, Hirooka Y, Nagayama T, Isegawa K, Katsuki M, Takesue K, Sunagawa K.
  • Journal Title: Int Heart J. Volume: 56 Pages: 110-115
  • DOI: 10.1536/ihj.14-168.
  • Peer Reviewed
• [Journal Article] Cardiac sympathetic afferent stimulation induces salt-sensitive sympathoexcitation through hypothalamic epithelial Na+ channel activation. (2015)
  • Author(s): Ito K, Hirooka Y, Sunagawa K.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 308 Pages: H530-H539
  • DOI: 10.1152/ajpheart.00586.2014.
  • Peer Reviewed
• [Journal Article] Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure. (2015)
  • Author(s): Sakamoto T, Kakino T, Sakamoto K, Tobushi T, Tanaka A, Saku K, Hosokawa K, Onitsuka K, Murayama Y, Tsutsumi T, Ide T, Sunagawa K.
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 308 Pages: H49-H58
  • DOI: 10.1152/ajpheart.00552.2014.
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Synergy of Neuro-Mechanical Unloading Strikingly Reduces the Infarct Size and Prevents Chronic Heart Failure in Ischemia Reperfusion Model. (2016)
  • Author(s): Arimura T, Saku K, Kakino T, Tohyama T, Nishikawa T, Murayama Y, Kishi T, Ide T, Sunagawa K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Twinkle Helicase Overexpression Prevents Cardiac Rupture after Myocardial Infarction by Alleviating Mitochondrial Insufficiency. (2016)
  • Author(s): Ikeda M, Ide T, Sunagawa K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Increased Expression of Thrombin Receptor, PAR1 is a New Therapeutic Target for Pulmonary Hypertension. (2016)
  • Author(s): Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Carotid Body Denervation Improves Survival via Sympatho-inhibition in Hypertensive Heart Failure. (2016)
  • Author(s): Fujii K, Saku K, Kishi T, Nishizaki A, Oga Y, Arimura T, Sunagawa K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] The Early Anti-inflammatory Responses of Vagal Nerve Stimulation Plays a Pivotal Role in Improving Chronic Heart Failure after Myocardial Infarction. (2016)
  • Author(s): Nishizaki A, Saku K, Oga Y, Kuwabara Y, Arimura T, Fujii K, Tohyama T, Nishikawa T, Kishi T, Ide T, Sunagawa K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Electrical Baroreflex Activation Improves Volume Load Induced Worsening of Heart Failure with Reduced Ejection Fraction. (2016)
  • Author(s): Oga Y, Sakamoto T, Saku K, NIshizaki A, Arimura T, Fujii K, Tohyama T, Nishikawa T, Murayama Y, Kishi T, Sunagawa K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Critical Protective Role of Endogenous Nitric Oxide in Severe Pulmonary Arterial Hypertension in Rats. (2016)
  • Author(s): Tanaka M, Abe K, Oka M, Schwenki D, Shirai M, Kuwahira I, Hirooka Y, Hoka S, Sunagawa K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] Acute Inflammation Activates the Sympathetic Nervous System by Resetting the Central Arc and Desensitizes the Peripheral Arc to Sympathoexcitation. (2016)
  • Author(s): Tohyama T, Saku K, Oga Y, Nishikawa T, Fujii K, Nishizaki A, Kishi T, Sunagawa K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] NF-κB-Mediated Inflammation Plays a Key Role in Deteriorating RV Function in Pulmonary Artery Banding Rats. (2016)
  • Author(s): Yoshida K, Abe K, Tanaka M, Shinoda M, Kuwabara Y, Saku K, Hirooka Y, Oka M, Sunagawa K.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2016-03-18 – 2016-03-20
• [Presentation] ntravascular Vagal Nerve Stimulation in Acute Myocardial Infarction Markedly Reduced Infarct Size and Improved Cardiac Function in the Long Term. (2015)
  • Author(s): Arimura T, Saku K, Kakino T, Akashi T, Nishikawa T, Mirayama Y, Takehara T, Ide T, Takuya K, Sunagawa K.
  • Organizer: Scientific Sessions 2015 of the American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Transvascular Total Left Ventricular Unloading for Acute Myocardial Infarction Strikingly Reduced Myocardial Oxygen Consumption, Limited the Infarct Size and Prevented Heart Failure in the long term (2015)
  • Author(s): Arimura T, Saku K, Kakino T, Akashi T, Murayama Y, Nishikawa T, Tohyama T, Ide T, Kishi T, Sunagawa K.
  • Organizer: Scientific Sessions 2015 of the American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Proteinase-activated Receptor 1 Antagonist Inhibited the Progression of Monocrotaline Induced Pulmonary Hypertension in Rats. (2015)
  • Author(s): Kuwabara Y, Abe K, Sunagawa K
  • Organizer: Scientific Sessions 2015 of the American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Input Impedance Analysis Of Pulmonary Hypertension Models Indicates That Monocrotaline And Sugen/hypoxia Induce Mechanically Different Vascular Remodeling (2015)
  • Author(s): Nishikawa T, Saku K, Sunagawa K
  • Organizer: Scientific Sessions 2015 of the American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] The anesthetized Rat Model of Exercise Faithfully Simulates Respiratory Abnormalities in Chronic Heart Failure (2015)
  • Author(s): Nishizaki A, Saku K, Oga Y, Fujii K, Arimura T, Takehara T, Akashi T, Murayama Y, Kishi T, Ide T, Sunagawa K.
  • Organizer: Scientific Sessions 2015 of the American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] VNS Induced Early Suppression of The Excessive Inflammatory Response May Contribute to Its Beneficial Effects on Chronic Heart Failure. (2015)
  • Author(s): Nishizaki A, Saku K, Oga Y, Fujii K, Arimura T, Takehara T, Akashi T, Murayama Y, Kishi T, Ide T, Sunagawa K.
  • Organizer: Scientific Sessions 2015 of the American Heart Association
  • Place of Presentation: Orland
  • Year and Date: 2015-11-07 – 2015-11-11
  • Int'l Joint Research
• [Presentation] Carotid Body Denervation Improves Survival with Sympatho-inhibition in Rats with Hypertensive Heart Failure. (2015)
  • Author(s): Fujii K, Saku K, Oga Y, Nishizaki A, Takehara T, Akashi T, Kishi T, Sunagawa K.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-22 – 2015-10-24
• [Presentation] The Akt-mTOR Axis is a Pivotal Regulator of Eccentric Hypertrophy during Volume Overload. (2015)
  • Author(s): Ikeda M, Ide T, Fujino T, Sunagawa K.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-22 – 2015-10-24
• [Presentation] Chronic Heart Failure Markedly Attenuates the Low Pressure Baroreflex in Regulating Sympathetic Function in Rats. (2015)
  • Author(s): Oga Y, Kishi T, Saku K, Nishizaki A, Arimura T, Fujii K, Tohyama T, Nishikawa T, Ide T, Sunagawa K.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-22 – 2015-10-24
• [Presentation] Right Ventricular Pressure-Volume Relationship to Evaluate Right ventricular-Pulmonary Aeterial Coupling and Energetics. (2015)
  • Author(s): Sakamoto T, Abe K, Hosokawa K, Oi K, Mukai Y, Yamazaki Y, Nagao M, Ide T, Sunagawa K.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-22 – 2015-10-24
• [Presentation] The Neuro-Mechanical Unloading for Acute Myocardial Infarction Markedly Reduce the Infarct Size and Prevents Heart Failure in the Long Term. (2015)
  • Author(s): Saku K, Arimura T, Kakino T, Sakamoto T, Tohyama T, Nishikawa T, Akashi T, Kishi T, Ide T, Sunagawa K.
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-22 – 2015-10-24
• [Presentation] 心不全はどこの、どんな病気としてとらえたらよいのか (2015)
  • Author(s): 砂川賢二
  • Organizer: 第19回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-11 – 2015-10-24
• [Presentation] Is renal nerve ablation a sound therpeutic strategy for the clinical treatment of HT? Insights gleaned from recent studies. (2015)
  • Author(s): Nishizaki A, Saku K, Sunagawa K.
  • Organizer: 25th Annual American Autonomic Society
  • Place of Presentation: Streasa
  • Year and Date: 2015-09-26 – 2015-09-29
  • Int'l Joint Research
• [Presentation] The vagal pathway to the viscera: from basic mechnisms to therapeotic applications. (2015)
  • Author(s): Nishizaki A, Saku K, Sunagawa K.
  • Organizer: 25th Annual American Autonomic Society
  • Place of Presentation: Streasa
  • Year and Date: 2015-09-26 – 2015-09-29
  • Int'l Joint Research
• [Presentation] Transvascular total left ventricular unloading in the acute phase of myocardial infarction markedly reduces infarct size and prevents heart failure in the long term. (2015)
  • Author(s): Saku K, Sunagawa K.
  • Organizer: European Society of Cardiology congress 2015
  • Place of Presentation: London
  • Year and Date: 2015-08-31 – 2015-09-03
  • Int'l Joint Research
• [Presentation] The Development of Pulmonary Artery Input Impedance in Experimental Pulmonary Hypertension. (2015)
  • Author(s): Nishikawa T, Saku K, Sakamoto T, Kishi T, Sunagawa K.
  • Organizer: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano
  • Year and Date: 2015-08-25 – 2015-08-29
  • Int'l Joint Research
• [Presentation] Baroreflex Activation Induced Sympathoinhibition Markedly Improves Hemodynamics in Rats with Reduced Ejection Fraction. (2015)
  • Author(s): Oga Y, Sakamoto T, Saku K, Tohyama T, Nishikawa T, Murayama Y, Akashi T, Kishi T, Sunagawa K.
  • Organizer: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano
  • Year and Date: 2015-08-25 – 2015-08-29
  • Int'l Joint Research
• [Presentation] Autonomic Regulation of the Pressure-Volume Relationship and Hemodynamics in Normal and Heart Failure. (2015)
  • Author(s): Sakamoto T, Sunagawa K
  • Organizer: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano
  • Year and Date: 2015-08-25 – 2015-08-29
  • Int'l Joint Research
• [Presentation] All about the Pressure-Volume Relationship of the Heart: From bench to Bedside and Beyond. (2015)
  • Author(s): Sunagawa K.
  • Organizer: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano
  • Year and Date: 2015-08-25 – 2015-08-29
  • Int'l Joint Research
• [Presentation] Closed Loop Neuromodulation in Cardiovascular Disease (2015)
  • Author(s): Sunagawa K, Saku K, Hosokawa K, Oga Y.
  • Organizer: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano
  • Year and Date: 2015-08-25 – 2015-08-29
  • Int'l Joint Research
• [Presentation] Experimental Acute Inflammation Induces Sympatho-Excitation Via the Resetting Baroreflex Neural Arc (2015)
  • Author(s): Tohyama T, Saku K, Nishikawa T, Oga Y, Takehara T, Akashi T, Kishi T, Ide T, Sunagawa K.
  • Organizer: The 37th anual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Milano
  • Year and Date: 2015-08-25 – 2015-08-29
  • Int'l Joint Research
• [Presentation] Carotid Body Denervation Attenuates Sympathetic Nerve Activity, Shifts the Pressure-Diuresis Curve to the Left and Improves Survival in rats with Hypertensive Heart Failure (2015)
  • Author(s): Fujii K, Saku K, KIshi T, Takehara T, Akashi T, Oga Y, NIshizaki A, Arimura T, Tohyama T, Nishikawa T, Sunagawa K.
  • Organizer: Experimental Biology 2015
  • Place of Presentation: San Diego
  • Year and Date: 2015-04-01 – 2015-04-01
  • Int'l Joint Research
• [Presentation] The Symptom Limited Up-titration of VNS May be Too Strong to Benefit Chronic Heart Failure before improving hemodynamics (2015)
  • Author(s): Nishizaki A, Saku K, Akashi T, Takehara T, Oga Y, Arimura T, Fujii K, Kishi T, Ide T, Sunagawa K.
  • Organizer: Experimental Biology 2015
  • Place of Presentation: San Diego
  • Year and Date: 2015-04-01 – 2015-04-01
  • Int'l Joint Research
• [Presentation] Chronic Heart Failure Blunts the Low Pressure Baroreflex Induced Biphasic Change of Sympathetic Nerve Activity (2015)
  • Author(s): Oga Y, Kishi T, Saku K, Kakino T, Nishizaki A, Arimura T, Fujii K, Tohyama T, Nishikawa T, Sunagawa K.
  • Organizer: Experimental Biology 2015
  • Place of Presentation: San Diego
  • Year and Date: 2015-04-01 – 2015-04-01
  • Int'l Joint Research
• [Presentation] Carotid Body Denervation Markedly Improves the Survival of Monocrotaline Induced Pulmonary Hypertension Rats. (2015)
  • Author(s): Shinoda M, Saku K, Abe K, Takehara T, Kuwabara Y, Yoshida K, Fujii K, Nishizaki A, Oga Y, Sunagawa K.
  • Organizer: Experimental Biology 2015
  • Place of Presentation: San Diego
  • Year and Date: 2015-04-01 – 2015-04-01
  • Int'l Joint Research