Creation of Functional Materials Using Polymer Self Assembly and Biomedical Application

2015 Fiscal Year Final Research Report

• Project/Area Number: 23225004
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Polymer chemistry
• Research Institution: Osaka University
• Principal Investigator: AKASHI Mitsuru 大阪大学, 生命機能研究科, 特任教授(常勤) (20145460)
• Co-Investigator(Kenkyū-buntansha): KIDA Toshiyuki 大阪大学, 大学院工学研究科, 教授 (20234297) ; MATSUSAKI Michiya 大阪大学, 大学院工学研究科, 准教授 (00419467) ; AKAGI Takami 大阪大学, 大学院生命機能研究科, 招聘研究員 (00527236) ; SHIMA Fumiaki 大阪大学, 大学院生命機能研究科, 特任助教 (60756659) ; AJIRO Hiroharu 奈良先端科学技術大学院大学, 先端科学技術研究推進センター, 特任准教授 (50437331) ; TABATA Masashi 独立行政法人国立病院機構都城病院, 歯科口腔外科, センター長 (60207214) ; MURAOKA Masahiro 大阪工業大学, 工学部, 教授 (80411411) ; WAKU Tomonori 京都工芸繊維大学, 工芸科学研究科, 助教 (30548699) ; HIRANO Hiroshi 独立行政法人大阪市立工業研究所, 加工技術研究部, 室長 (10416349)
• Co-Investigator(Renkei-kenkyūsha): SAWA Yoshiki 大阪大学, 大学院医学系研究科, 教授 (00243220) ; HASHIMOTO Koji 愛媛大学, 大学院医学研究科, 教授 (00110784)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 高分子化学 / 高分子薄膜・表面 / 交互積層法

Outline of Final Research Achievements

We studied the fundamental research of Layer-by-Layer (LbL) technique which employed weak polymer-polymer interactions, and created the polymeric materials made by LbL method. We demonstrated that the stereocomplexes prepared by LbL of stereoregular polymers showed high thermal stability, mechanical strength, and so on. On the other hand, we successfully fabricated the 3D tissues by coating extracellular matrix (ECM) nanofilms onto cell surfaces using LbL assembly. Moreover, our method could introduce blood vessel structures into tissues. By using these techniques, we could fabricate cancer models, cardiac tissues, skin models and revealed that these tissues would be useful for pharmaceutical applications and regenerative medicine. We also created the dental materials and novel vaccine systems. These results clearly demonstrated that fundamental researches of chemistry and polymer chemistry created a new field in biomedical area, and could provide novel approaches to the medical field.

Free Research Field

高分子化学