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2017 Fiscal Year Final Research Report

Construction of novel detector system for structural biology using ultrafast fine pixel detector

Research Project

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Project/Area Number 23227003
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Structural biochemistry
Research InstitutionHigh Energy Accelerator Research Organization

Principal Investigator

Wakatsuki Soichi  大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 研究員 (00332114)

Co-Investigator(Kenkyū-buntansha) 後田 裕  大学共同利用機関法人高エネルギー加速器研究機構, 素粒子原子核研究所, 教授 (10342601)
三宅 秀樹  大学共同利用機関法人高エネルギー加速器研究機構, 素粒子原子核研究所, 研究機関講師 (20403115)
清水 伸隆  大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (20450934)
樋口 岳雄  東京大学, カブリ数物連携宇宙研究機構, 准教授 (40353370)
松垣 直宏  大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (50342598)
田中 秀治  大学共同利用機関法人高エネルギー加速器研究機構, 素粒子原子核研究所, 准教授 (80311124)
原 康二  大学共同利用機関法人高エネルギー加速器研究機構, 素粒子原子核研究所, 助教 (90432236)
Co-Investigator(Renkei-kenkyūsha) KONNO Tomoyuki  高エネ機構, 素粒子原子核研究所, 研究員 (60751518)
KOBAYASHI Aine  高エネ機構, 素粒子原子核研究所, 研究員 (50794749)
PULVERMACHER Christian  高エネ機構, 素粒子原子核研究所, 研究員 (10788087)
Research Collaborator Kiesling Christian  
Andricek Ladislav  
Koffmane Christian  
Ninkovic Jelena  
Moser Hans-Günther  
Muller Felix B.  
Konorov Igor  
Rummel Stefan  
Ritter Martin  
Project Period (FY) 2011-04-01 – 2016-03-31
Keywordsピクセル検出器 / タンパク質結晶構造解析 / タンパク質溶液散乱
Outline of Final Research Achievements

We have developed a high-resolution and high-speed readout detector for protein structural analysis, based on the latest pixel detector DEPFET (DEpleted P-channel Field Effect Transistor) developed for particle physics. Evaluation experiments using synchrotron radiation X-rays showed that diffraction images from protein crystals or solutions can be taken with better positional accuracy with DEPFET than existing X-ray detectors, and the hit information can be read out in high frame rate. By arranging sensor modules side by side to constitute a megapixel class large area detector, it is expected to be applied to microcrystal structure analysis of highly difficult proteins or time-resolved solution scattering, and to lead opening up new measurement and analysis techniques.

Free Research Field

構造生物学

URL: 

Published: 2019-03-29  

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