Analysis of the regulation and mode of action of atypical G-protein cycles

2016 Fiscal Year Final Research Report

• Project/Area Number: 23229001
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: KATADA TOSHIAKI 東京大学, 大学院薬学系研究科(薬学部), 教授 (10088859)
• Co-Investigator(Renkei-kenkyūsha): KONTANI Kenji 明治薬科大学, 薬学部, 教授 (30302615) ; KAJIHO Hiroaki 東京大学, 大学院薬学系研究科, 助教 (70401221) ; FUKUYAMA Masamitsu 東京大学, 大学院薬学系研究科, 講師 (20422389) ; SAITO Kota 東京大学, 大学院薬学系研究科, 助教 (60549632)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: タンパク質 / 遺伝子 / シグナル伝達 / Ｇタンパク質 / 小胞輸送 / 栄養センシング

Outline of Final Research Achievements

G proteins, which cycle between the two different GTP- and GDP-bound conformations (G cycles), play important roles as a "molecular switch" in many intracellular signaling pathways. In the Grant-in-Aid for Scientific Research (S), we investigated how the G cycles of atypical G proteins are regulated dependent on their modes of actions in intracellular vesicle transport system and found that the novel G proteins containing unique biochemical properties and/or structures are involved in the regulation of endosome dynamics, such as lysosome biogenesis, endocytosis, and exocytosis.

Free Research Field

生物系薬学、機能生物化学