2016 Fiscal Year Final Research Report
Immunological crosstalk between nasal and reproductive mucosal tissue
| Project/Area Number |
23229004
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
|
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2016-03-31
|
| Keywords | 粘膜免疫 / 経鼻ワクチン / HSV2 / アジュバント |
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| Outline of Final Research Achievements |
The antigen administration to the nasal mucosa induces not only the immune responses in the nasal mucosa but reproductive tissue even its distant parts in our body. Therefore, the elucidation of molecular and cellular mechanisms of the nasal-reproductive mucosal crosstalk would be connected for the development of next generation mucosal vaccine for sexually transmitted diseases caused by HIV and HSV. In this project, we aim to identify the responsible molecule for the crosstalk and finally and successfully identified the contribution of unique chemoattractant pathways. In addition, we confirmed the safety of the nasal vaccine with our novel mucosal vaccine developed by nanoparticles and found no dissemination of antigen to the brain in mice and monkey study and found its safety.
These results collectively indicated the successful establishment of basic approval methods for the mucosal vaccine targeting immunological crosstalk between nasal and reproductive mucosal tissue.
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| Free Research Field |
免疫学、粘膜免疫学
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