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2015 Fiscal Year Final Research Report

Development of rheumatoid arthritis-directed human immunology

Research Project

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Project/Area Number 23229007
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAMOTO KAZUHIKO  東京大学, 医学部附属病院, 教授 (80191394)

Co-Investigator(Kenkyū-buntansha) OKAMURA TOMOHISA  東京大学, 医学部附属病院, 特任助教 (10528996)
SHODA HIROFUMI  東京大学, 医学部附属病院, 助教 (20529036)
SUMITOMO SHUJI  東京大学, 医学部附属病院, 助教 (20392996)
SHIBUYA MIHOKO  東京大学, 医学部附属病院, 助教 (20366363)
IWASAKI YUKIKO  東京大学, 医学部附属病院, 助教 (30592935)
Project Period (FY) 2011-04-01 – 2016-03-31
Keywordsゲノム / 内科 / 免疫学 / 組織・細胞 / 生体分子
Outline of Final Research Achievements

This project aimed to address the function of lymphocytes in rheumatoid arthritis(RA) with regard to (1) regulatory T cells (Treg), (2) gene polymorphisms, and (3) antigen-specific CD4+ T cells. (1) TGF-beta3 producing LAG3+Treg were identified in mice and the frequency of LAG3+Treg showed a significant decrease in active RA. (2) Transcriptome and genome wide polymorphism examinations in 100 healthy controls enabled us to establish a method predicting transcriptome from genetic polymorphisms. (3) Effector and regulatory T cells recognized different BiP epitopes and their balance showed a deviation toward BiP-specific effector T cells.

Free Research Field

リウマチ・アレルギー・免疫学

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Published: 2017-05-10  

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