2015 Fiscal Year Final Research Report
Real-World Modeling on the Hierarchical Dynamics of Living System
| Project/Area Number |
23240044
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Doshisha University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUMOTO Kanta 三重大学, 工学研究科, 講師 (80362359)
MOTOIKE Ikuko 東北大学, 情報学研究科, 准教授 (70347178)
ICHIKAWA Masatoshi 京都大学, 理学研究科, 講師 (40403919)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 時空間秩序 / 生命物理学 / ゲノムDNA / 人工細胞モデル / 形態形成のモデル / DNA二本鎖損傷 / DNA高次構造 / 細胞サイズ小胞 |
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| Outline of Final Research Achievements |
We studied the dynamical aspects of life accompanied by the development of physical consideration, by considering the hierarchical structure: 1) On-off switching of large number of genes embedded in genomic DNA. Biological significance of the discrete nature of the conformational transition was theoretically discussed in relation to robust on/off switching of large number of genes on the process of cell-differentiation. 2) Field hypothesis on living cell. It was shown that unique physic-chemical properties emerge in micro systems, which may concern with the life activity of living cells. 3)Novel non-Turing scenario of body-organization during development was proposed and simple theoretical modeling was successfully achieved.
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| Free Research Field |
生命物理学
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