The conprehensive study for the interaction between environmental and genetic factors associated with amount of physical activity of Japanese population

2014 Fiscal Year Final Research Report

• Project/Area Number: 23240089
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical education
• Research Institution: National Institute of Health and Nutrition
• Principal Investigator: MIYACHI Motohiko 独立行政法人国立健康・栄養研究所, 健康増進研究部, 部長 (60229870)
• Co-Investigator(Renkei-kenkyūsha): MURAKAMI Haruka 独立行政法人国立健康, 栄養研究所・健康増進研究部, 研究員 (20344880) ; SANADA Kiyoshi 立命館大学, スポーツ健康科学部, 教授 (50421227) ; IEMITSU Motoyuki 立命館大学, スポーツ健康科学部, 教授 (90375460) ; FUKU Noriyuki 順天堂大学, 大学院スポーツ健康科学研究科, 准教授 (40392526) ; YASUNAGA Akitomo 文化学園大学, 現代文化学部, 准教授 (30289649) ; YANO Hiromi 川崎医療福祉大学, 医療技術学部, 准教授 (20248272)
• Research Collaborator: KAWAKAMI Ryoko
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 身体活動 / 環境 / 遺伝 / 免疫 / 疫学 / 生理学 / 生化学

Outline of Final Research Achievements

There is large Individual variations in physical activity. This may be associated with differences in the environmental, genetic and trait, and fatigue and infectious factors. Our studies indicated that 1) high-intensity physical activity was associated with a plurality of SNPs in chromosome 4 and 8, 2) mitochondrial DNA polymorphism was associated with the strength and agility, 3) shopping and living environments were associated with walking and physical activity, and 4) the interaction of intestinal immunity and intestinal flora were associated to changes in physical activity. These findings suggest that the variability of physical activity may be affected by some internal and external factors, moreover immunity and infection.

Free Research Field

運動生理学