Synthesis of artificial modulator for cancer signalling by motif programming.

2014 Fiscal Year Final Research Report

• Project/Area Number: 23240135
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: SHIBA Kiyotaka 公益財団法人がん研究会, その他部局等, その他 (40196415)
• Research Collaborator: ITO Masaki
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 合成生物学 / 信号伝達 / 細胞性免疫 / 人工タンパク質 / 進化工学 / コンビナトリアル / アジュバント / モチーフ

Outline of Final Research Achievements

The aim of this study is the establishment of design principle for the creation of artificial antigens for cellular immunity. For this purpose, we prepared the library for artificial proteins from combinatorial polymerization of "MHC class I epitope", "MHC class II epitope" and the "peptide sequences having the propensities to form secondary structures", from which we have successfully selected the clones that can efficiently evoke in vitro and in vivo cellular immunity without the co-addition of physical adjuvant such as mineral oil or aluminum hydroxide.

Free Research Field

分子生物学