Molecular basis of intercellular communication by Hippo pathway

2015 Fiscal Year Final Research Report

• Project/Area Number: 23247036
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Osaka University (2015); Kumamoto University (2011-2014)
• Principal Investigator: SASAKI Hiroshi 大阪大学, 生命機能研究科, 教授 (10211939)
• Co-Investigator(Renkei-kenkyūsha): HIRATE Yoshikazu 熊本大学, 発生医学研究所, 助教 (70342839) ; WADA Ken-ichi 独立法人理化学研究所, 胚誘導研究チーム, 研究員 (20525919) ; MAMADA Hiroshi 熊本大学, 発生医学研究所, 研究員 (90568734) ; SATO Takashi 熊本大学, 発生医学研究所, 研究員 (70555755) ; KAMURA Keiichiro 大阪大学, 大学院生命機能研究科, 特任助教 (30604483)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 細胞間コミュニケーション / Hippoシグナル / 細胞競合

Outline of Final Research Achievements

During embryogenesis, behaviors of individual cells are coordinated。In this research, we focused on Hippo signaling pathway, which is involved in intercellular communication, and found involvement of F-actin cytoskeleton and Angiomotin present at adherens junctions. We also found that cells recognize differences in Tead activities with neighboring cells and undergo cell competition, and that such communication is an universal mechanism, which also takes place in mouse embryos. These communication mechanisms likely contribute to coordinate cellular behaviors in mouse embryos.

Free Research Field

発生生物学