Ontogeny and phylogeny of A-P axis and germ layer formation in amniotes

2014 Fiscal Year Final Research Report

• Project/Area Number: 23247037
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: AIZAWA Shinichi 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員 (60073011)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 前後軸形成 / 羊膜類 / マウス / ニワトリ / スッポン / ゲッコー / オッポッサム / 真獣類

Outline of Final Research Achievements

Anterior-posterior (A-P) axis determination and germ-layer formation are most fundamental steps in animal development. In amniotes their mechanisms have been studied in mouse and chick. The mechanisms are so diverged between them that no consensus has been established about the prototype in amniotes and the divergences in mammal and avian. To examine the question, comparative analyses were made in eutherian (mouse, rabbit, pig, Suncus), reptile (gecko, turtle), avian (chick, quail), and metatherian (opossum). The studies have revealed unexpected phylogenetic changes in amniote A-P axis and germ layer formation.

Free Research Field

生物学