2014 Fiscal Year Final Research Report
Assessment of maternal factors that naturally strengthen the function of offsprings.
| Project/Area Number |
23248049
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MOGI Kazutaka 麻布大学, 獣医学部, 准教授 (50347308)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGASAWA Miho 自治医科大学, 医学部, ポストドクター (70533082)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | 早期離乳 / グルココルチコイド / 前頭葉 / エピジェネティクス / 母性因子 |
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| Outline of Final Research Achievements |
In the present study, we aimed to reveal the neural and molecular mechanisms induced by the early weaning and new methods to improve the developmental period are challenged. In the first experiment, we found that excessive glucocorticoid secretion after early weaning, and this glucocorticoid is the key to induce the higher anxiety in the early-weaned mouse. In the prefrontal cortex of the early-weaned mice, FKBP5 increased and the expression level of FKBP5 was negatively correlated with the anxiety level. The pups staying with the dam showed higher oxytocin secretion in the anterior cingulate cortex, and this oxytocin concentration was positively associated with the duration time of physical contact with the dam. Finally, we introduced a alloparental female, which was not the biological mother but showed the similar maternal behavior toward the pups, and observed the adult phenotypes of the early-weaned mouse. Some parameters were partially recovered by the alloparenting in male mice.
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| Free Research Field |
動物行動学
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