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2013 Fiscal Year Final Research Report

Integrated molecular analysis of taste signal generation, transmission and cognition

Research Project

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Project/Area Number 23248058
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied molecular and cellular biology
Research InstitutionThe University of Tokyo

Principal Investigator

ABE Keiko  東京大学, 農学生命科学研究科, 特任教授 (10151094)

Co-Investigator(Kenkyū-buntansha) AIZAWA Hiroyuki  東京大学, 大学院農学生命科学研究科, 特任准教授 (90221704)
Co-Investigator(Renkei-kenkyūsha) ISHIMARU Yoshiro  東京大学, 大学院農学生命科学研究科, 特任准教授 (10451840)
OKADA Shinji  東京大学, 大学院農学生命科学研究科, 特任准教授 (50376563)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords食品 / 味覚 / 脳・神経 / シグナル伝達 / 細胞・組織
Research Abstract

Outline of the research: For the integrated analysis of taste systems, (1) we found the target genes AnoI, Kene3, Sec61a1 that are involved in construction of electric potential of saltiness reception (type I) cell membrane; (2) PLC-beta2-WGA medaka fish analysis led to comprehensive elucidation of the taste transmission pathway from bitterness/amino acid receiving cells to the endbrain and the visualization of saltiness-receiving cell to the NST taste area in PKD1L3-WGA mice was successive; and (3) integrated expression markers in weaning mice, SNAP25, EGr-2 and Krox-20, were distinctly activated its signal in the taste area when the mice were given a solid food at the stage of weaning in comparison with the case that they were still given a liquid food. (4) we also showed that there is a relationship between the tastant quality in diet and the food intake.

  • Research Products

    (31 results)

All 2013 2012 2011

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (7 results)

  • [Journal Article] (7/8) Effects of inhaled (S)-linalool on hypothalamic gene expression in rats under restraint stress2013

    • Author(s)
      Yamamoto, Abe, K.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 77 Pages: 2413-2418

    • DOI

      10.1271/bbb.130524

    • Peer Reviewed
  • [Journal Article] (4,10/10) Influence of a short-term iron-deficient diet on hepatic gene expression profiles in rats2013

    • Author(s)
      Kamei, A., Okada, S., Abe, K.
    • Journal Title

      PLoS ONE

      Volume: 8 Pages: e65732

    • DOI

      10.1371/journal.pone.0065732

    • Peer Reviewed
  • [Journal Article] Introduction : Taste Perception2013

    • Author(s)
      Abe, K.
    • Journal Title

      Semin. Cell Dev. Biol.

      Volume: 24 Pages: 199

    • DOI

      10.1016/j.semcdb.2013.03.003

    • Peer Reviewed
  • [Journal Article] (3/3) Functional diversification of taste cells in vertebrates2013

    • Author(s)
      Matsumoto, I., Abe, K.
    • Journal Title

      Semin. Cell Dev. Biol.

      Volume: 24 Pages: 210-214

    • DOI

      10.1016/j.semcdb.2012.10.004

    • Peer Reviewed
  • [Journal Article] (7,8,9/10) Differential expression analysis throughout the weaning period in the mouse cerebral cortex2013

    • Author(s)
      Maeda, N., Okada, S., Abe, K., Aizawa, H.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 431 Pages: 437-443

    • DOI

      10.1016/j.bbrc.2012.12.150

    • Peer Reviewed
  • [Journal Article] (2,5/7) Transgenic labeling of higher-order neuronal circuits linked to phosphorlipase C-β2-expressing taste bud cells in medaka fish2013

    • Author(s)
      Ieki, T., Okada, S., Abe, K.
    • Journal Title

      J. Comp. Neurol.

      Volume: 521 Pages: 1781-1802

    • DOI

      10.1002/cne.23256

    • Peer Reviewed
  • [Journal Article] Accumulation of SNAP25 in mouse gustatory and somatosensory cortices in response to food and chemical stimulation2012

    • Author(s)
      Kawakami, S., et. al.
    • Journal Title

      Neuroscience

      Volume: 218 Pages: 326-334

    • DOI

      10.1016/j.neuroscience.2012.05.045

    • Peer Reviewed
  • [Journal Article] (5/5) Expression analysis of taste signal transduction molecules in the fungiform and circumvallate papillae of the rhesus macaque, Macaca mulatta2012

    • Author(s)
      Ishimaru, Y., Abe, K.
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e45426

    • DOI

      10.1371/journal.pone.0045426

    • Peer Reviewed
  • [Journal Article] Studies on food functionality and safety in Japan.Evaluation by genomics2012

    • Author(s)
      Abe, K.
    • Journal Title

      J. Food and Drug Analysis

      Volume: 20 Pages: 208-212

    • Peer Reviewed
  • [Journal Article] (6,7/8) Identification of bitterness-masking compounds from cheese2012

    • Author(s)
      Homma, R., Ishimaru, Y., Abe, K.
    • Journal Title

      J Agric. Food Chem.

      Volume: 60 Pages: 4492-4499

    • DOI

      10.1021/jf300563n

    • Peer Reviewed
  • [Journal Article] (5/7) Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds2012

    • Author(s)
      Masuda, K., Abe, K.
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: e35380

    • DOI

      10.1371/journal.pone.0035380

    • Peer Reviewed
  • [Journal Article] (3,7/9) Functional diversity of bitter taste receptor TAS2R16 in primates2012

    • Author(s)
      Imai, H., Ishimaru, Y., Abe, K.
    • Journal Title

      Biol. Lett.

      Volume: 8 Pages: 652-656

    • DOI

      10.1098/rsbl.2011.1251

    • Peer Reviewed
  • [Journal Article] (4,5/6) The use of mammalian cultured cells loaded with a fluorescent dye shows specific membrane penetration of undissociated acetic acid2012

    • Author(s)
      Ishii, S., Okada, S., Abe, K.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 76 Pages: 523-529

    • DOI

      10.1271/bbb.110824

    • Peer Reviewed
  • [Journal Article] (4,6/7) Sweeteners interacting with the trans-membrane domain of the human sweet-taste receptor induce sweet-taste synergisms in binary mixtures2012

    • Author(s)
      Fujiwara, S., Okada, S., Abe, K.
    • Journal Title

      Food Chem.

      Volume: 130 Pages: 561-568

    • DOI

      10.1016/j.foodchem.2011.07.073

    • Peer Reviewed
  • [Journal Article] (2,6/6) Genetic tracing of the gustatory neural pathway originating from PKD1l3-expressing type III taste cells in circumvallate and foliate papillae2011

    • Author(s)
      Yamamoto, K., Ishimaru, Y., Abe, K.
    • Journal Title

      J. Neurochem.

      Volume: 119 Pages: 497-506

    • DOI

      10.1111/j.1471-4159.2011.07443.x

    • Peer Reviewed
  • [Journal Article] (10/10) Human sweet taste receptor mediates acid-induced sweetness of miraculin2011

    • Author(s)
      Koizumi, A., Abe, K.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 108 Pages: 16819-16824

    • DOI

      10.1073/pnas.1016644108

    • Peer Reviewed
  • [Journal Article] (10/10) Polyphenols in alcoholic beverages activating constitutive androstane receptor, CAR2011

    • Author(s)
      Yao, R., Abe, K.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 75 Pages: 1635-1637

    • DOI

      10.1271/bbb.110444

    • Peer Reviewed
  • [Journal Article] (3,4/5) Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides2011

    • Author(s)
      Ueno, Y., Okada, S., Abe, K.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 75 Pages: 1188-1190

    • DOI

      10.1271/bbb.100893

    • Peer Reviewed
  • [Journal Article] (5/5) Skn-1a (Pou2f3) specifies taste receptor cell lineage2011

    • Author(s)
      Matsumoto, I., Abe, K.
    • Journal Title

      Nat. Neurosci.

      Volume: 14 Pages: 685-687

    • DOI

      10.1038/nn0911-1217f

    • Peer Reviewed
  • [Journal Article] (10/10) Non-acidic compounds induce the intense sweet taste of neoculin, a taste-modifying protein2011

    • Author(s)
      Nakajima, K., Abe, K.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 75 Pages: 1600-1602

    • DOI

      10.1271/bbb.110081

    • Peer Reviewed
  • [Journal Article] (11/11) Identification and modulation of the key amino acid residue responsible for the pH sensitivity of Neoculin, a taste-modifying protein2011

    • Author(s)
      Nakajima, K., Abe, K.
    • Journal Title

      PLoS ONE

      Volume: 6 Pages: e19448

    • DOI

      10.1371/journal.pone.0019448

    • Peer Reviewed
  • [Journal Article] (7/10) Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans2011

    • Author(s)
      Ito, K., Abe, K.
    • Journal Title

      J. Mol. Biol.

      Volume: 408 Pages: 177-186

    • DOI

      10.1016/j.jmb.2011.02.028

    • Peer Reviewed
  • [Journal Article] (2,4/5) Mutually exclusive expression of Gαia and Gα14 reveals diversification of taste receptor cells in zebrafish2011

    • Author(s)
      Ohmoto, M., Okada, S., Abe, K.
    • Journal Title

      J. Comp. Neurol.

      Volume: 519 Pages: 1616-1629

    • DOI

      10.1002/cne.22589

    • Peer Reviewed
  • [Journal Article] (2,7/7) The single pore residue Asp523 in PKD2L1 determines Ca2+ permeation of a PKD1L3/PKD2L1 complex2011

    • Author(s)
      Fujimoto, C., Ishimaru, Y., Abe, K.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 404 Pages: 946-951

    • DOI

      10.1016/j.bbrc.2010.12.086

    • Peer Reviewed
  • [Presentation] マウス小腸上皮における味覚関連遺伝子群の発現解析2013

    • Author(s)
      吉岡美紗子, 他
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-27
  • [Presentation] 人工甘味料の摂取がマウス肝臓遺伝子発現プロファイルに与える影響の網羅的解析2013

    • Author(s)
      牛尼翔太, 他
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-25
  • [Presentation] 味神経における味覚情報コーディング機構の解析2012

    • Author(s)
      前田尚廣, 他
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-24
  • [Presentation] メダカPLC-β2発現細胞を起点とした経シナプス性トレーサー輸送の経時的解析2012

    • Author(s)
      家木誉史, 他
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-24
  • [Presentation] 味蕾におけるアノクタミンファミリーの細胞種特異的発現2012

    • Author(s)
      黒川あずさ, 他
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-23
  • [Presentation] ヒト甘味受容体における低分子甘味物質の相互作用部位の同定2011

    • Author(s)
      古泉文子, 他
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26
  • [Presentation] 離乳マウスの脳体性感覚野におけるSNAP25発現の経時変化2011

    • Author(s)
      伊藤俊輔, 他
    • Organizer
      日本農芸化学会2011年度大会
    • Place of Presentation
      京都
    • Year and Date
      2011-03-26

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Published: 2015-06-25  

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