New development of diagnostic and therapeutic modality for ischemia/reperfusion injury by intelligent DDS

2014 Fiscal Year Final Research Report

• Project/Area Number: 23249005
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: OKU Naoto 静岡県立大学, 薬学部, 教授 (10167322)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Kosuke 静岡県立大学, 薬学部, 講師 (30423841) ; TAKEDA Atsushi 静岡県立大学, 薬学部, 教授 (90145714)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 脳梗塞 / 虚血再灌流障害 / 薬物送達システム / ＤＤＳ / リポソーム / 脳保護薬 / ナノ粒子 / 運動機能

Outline of Final Research Achievements

Cerebrovascular disease, stroke, is the fourth leading cause of death in Japan, and the first position of the number of people certiflied for long-term care. Cerebral infarction occupies about 60% of the disease. This study aimed to create a new drug by use of drug delivery system which delivers the drug to the ischemic site. Although transport of materials from bloodstream to brain tissue is strictly regulated in normal brain, this barrier (blood-brain barrier) is degenerated in cerebral infarction. We observed that 100 nm-sized liposome, a lipid-based microcapsule, could enter the ischemic brain tissues. We modified a certain protein having neuro protective effect on the liposomal surface or incorporated some neuro protective drugs in liposomes. These liposomes protected the brain cell death by infarction, and suppressed the decrease in motor function, an indicator of the aftereffect by brain infarction.

Free Research Field

薬物送達学