2014 Fiscal Year Final Research Report
Comparison Western Japan with Eastern Japan about the cause of asymptomatic cerebrovascular disorders and hippocampal atrophy in general Japanese men
| Project/Area Number |
23249036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UESHIMA Hirotsugu 滋賀医科大学, アジア疫学研究センター, 特任教授 (70144483)
IMAI Yutaka 東北大学, 薬学研究科, 教授 (40133946)
MURATA Kiyoshi 滋賀医科大学, 医学部, 教授 (20127038)
NOZAKI Kazuhiko 滋賀医科大学, 医学部, 教授 (90252452)
SHIINO Akihiko 滋賀医科大学, 分子神経科学研究センター, 准教授 (50215935)
OHKUBO Takayoshi 帝京大学, 医学部, 教授 (60344652)
HOSAWA Atsushi 東北大学, 東北メディカル・メガバンク機構, 教授 (00432302)
FUJIYOSHI Akira 滋賀医科大学, 医学部, 准教授 (10567077)
HISAMATSU Takashi 滋賀医科大学, アジア疫学研究センター, 特任助教 (60710449)
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| Co-Investigator(Renkei-kenkyūsha) |
HORIE Minoru 滋賀医科大学, 医学部, 教授 (90183938)
TOHYAMA Ikuo 滋賀医科大学, 分子神経科学研究センター, 教授 (20207533)
TOTSUNE Kazuhito 東北福祉大学, 総合マネジメント学部, 教授 (10217515)
ARAI Hiroyuki 東北大学, 加齢医学研究所, 教授 (30261613)
MURAKAMI Yoshitaka 東邦大学, 医学部, 教授 (90305855)
KADOTA Aya 滋賀医科大学, アジア疫学研究センター, 特任准教授 (60546068)
KIKUYA Masahiro 東北大学, 東北メディカル・メガバンク機構, 准教授 (80361111)
NAGASAWA Shin-ya 金沢医科大学, 健康管理センター, 助教 (30510341)
ASAYAMA Kei 帝京大学, 医学部, 講師 (80431518)
TOMITA Naoki 東北大学, 加齢医学研究所, 助教 (00552796)
TAKASHIMA Naoyuki 滋賀医科大学, 医学部, 学内講師 (80435883)
HIROSE Takuo 東北大学, 医学研究科, 助教 (20599302)
SEKIKAWA Akira 滋賀医科大学, 医学部, 客員准教授 (10216525)
KONDO Takeo 東北大学, 大学病院, 講師 (30282130)
MIKI Tetsuro 愛媛大学, 医学部, 教授 (00174003)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | 社会医学 / 循環器・高血圧・疫学 / 脳卒中 / コホート研究 / 頭部MRI / 潜在性動脈硬化 |
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| Outline of Final Research Achievements |
Stroke mortality is low in the Western Japan, while high in the Eastern Japan. In this study, we performed brain magnetic resonance imaging (MRI) in participants of cohort studies at Kusatsu (west) and Ohasama (east). First, we conducted MRI in same participants living in Ohasama at both Kusatsu and Ohasama facilities to investigate validity comparing West and East. Kappa coefficients between two facilities were about 0.60 in lacunar infarction and cerebral microbleed, 0.46 in white matter lesion. Then, we compared people in Kusatsu with these in Ohasama aged from 60 to 89 by age. Prevalence of lacunar infarction and that of cerebral microbleed were higher in Ohasama than in Kusatsu, and we thought that it might be occurred because people in Ohasama had higher blood pressure and percentage of medication of hypertension than Kusatsu in baseline characteristics. Meanwhile prevalence of white matter lesion was higher in Kusatsu than in Ohasama. That reason was not clear.
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| Free Research Field |
予防医学
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