Next generation sequencing-based elucidation of novel hormone action targets for geriatric diseases and application for anti-aging medicine

2014 Fiscal Year Final Research Report

• Project/Area Number: 23249040
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: INOUE Satoshi 東京大学, 医学部附属病院, 特任教授 (40251251)
• Co-Investigator(Kenkyū-buntansha): URANO Tomohiko 東京大学, 医学部附属病院, 講師 (20334386)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 老化 / 核内受容体 / エストロゲン / アンドロゲン / ビタミンK / 次世代シーケンサー / 非コードRNA / ゲノムワイド解析

Outline of Final Research Achievements

In this study, we elucidated molecular mechanisms of hormone actions in aging and geriatric diseases at whole body, tissue, and cell levels based on next generation sequencing and revealed novel hormone signaling and cross-talk pathways including the functions of novel target molecules, interacting factors, and modification factors. In particular, we elucidated action mechanisms of androgen-responsive long noncoding RNA CTBP1-AS and microRNAs, an androgen target gene APP, androgen receptor-collaborating factors Oct1 and CtBP2, estrogen target genes COX7RP and Efp, and vitamin K action modulators GGCX and SXR. We also clarified their relevance in the anti-aging medicine as molecular targets for prevention, diagnosis, and therapy of age-related and geriatric diseases.

Free Research Field

ゲノム医学、内分泌代謝学