2015 Fiscal Year Final Research Report
The investigation of genes related to refractory respiratory diseases and development of novel therapeutics
| Project/Area Number |
23249045
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU TAKAO 東京大学, 大学院医学系研究科, 特任教授 (80127092)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | ＣＯＰＤ / 肺線維症 / ARDS |
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| Outline of Final Research Achievements |
In respiratory diseases, there are several refractory disorders such as COPD, ARDS and pulmonary fibrosis, to which no pharmaceutical agents are currently available or effective. However, their mechanisms still remain to be elucidated. The purpose of this project is to investigate the roles of lipid mediators and TAZ in these disorders using genetically-engineered mice. We found that lipid mediators and TAZ were involved in the pathogenesis of these lung disorders. Our results suggest that these mediators might provide a novel therapeutic approach to these diseases.
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| Free Research Field |
呼吸器内科学
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