2015 Fiscal Year Final Research Report
Novel Approach for Treatment of Glomeruloclerosis
| Project/Area Number |
23249047
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSAKA Taiji 東海大学, 医学部・内科, 准教授 (50317749)
MOTOJIMA Masaru 東海大学, 医学部・薬理学, 講師 (80468636)
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| Research Collaborator |
Pastan Ira National Institutes of Health, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Professor
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | ポドサイト傷害 / 慢性腎不全 / 糸球体硬化症 / タンパク尿 |
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| Outline of Final Research Achievements |
Kidney diseases are major national health problems. Various causes including nephritis and diabetes leads to injury in “podocytes” in the kidney, which leads to loss of the whole kidney function. Damage in a subpopulation of podocytes secondarily propagates injury to the neighboring podocytes. In this project, we have established a mouse model in which injury to a fraction of the podocyte population can be induced, analyzed how the podocyte injury spreads and identified several key molecules potentially involved in the propagation of injury. It is expected that drugs targeting these molecules would forestall the progression of kidney diseases.
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| Free Research Field |
腎臓病学
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